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Deciphering Congenital Heart Disease Using Human Induced Pluripotent Stem Cells
Congenital heart disease (CHD) is a leading cause of birth defect-related death. Despite significant advances, the mechanisms underlying the...
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Differentiation of Human Embryonic/Induced-Pluripotent Stem Cells to Retinal Ganglion Cells
The generation of retinal ganglion cells (RGCs) differentiated from human embryonic stem cell (hESC) or induced-pluripotent stem cells (iPSC) could...
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Modeling the Blood-Brain Barrier Using Human-Induced Pluripotent Stem Cells
The blood-brain barrier (BBB) is a key physiological component of the brain, protecting the brain from peripheral processes and pathogens. The BBB is...
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Reprogramming of Normal Cells into Human Pluripotent Stem Cells
Human pluripotent stem cells (hPSCs) have the potential to become the source of materials for cell-based therapy. The similarity of hPSCs with the...
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Maintenance of Human Pluripotent Stem Cells
During the last decades, the field of stem cell research has rapidly expanded with the potential to develop the technology of tissue regeneration as...
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Generation of Oligodendrocytes from Human Pluripotent and Embryonic Stem Cells
Oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes (OLs) can be generated using human induced pluripotent stem cells (hiPSCs) and...
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Comparison of retinal degeneration treatment with four types of different mesenchymal stem cells, human induced pluripotent stem cells and RPE cells in a rat retinal degeneration model
BackgroundRetinal degeneration (RD) is a group of disorders on irreversible vision loss. Multiple types of stem cells were used in clinical trials...
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Cerebellar Modelling Using Human Induced Pluripotent Stem Cells
Human induced pluripotent stem cells (hiPSCs) have changed the way human development and disease are studied. It is now increasingly possible to...
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CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth
Cyclin-dependent kinase 5 (CDK5) is a protein kinase involved in neuronal homeostasis and development critical for neuronal survival. Besides, its...
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Cell therapy for Parkinson’s disease with induced pluripotent stem cells
Parkinson’s disease (PD) is the second most common neurodegenerative disease and a prime target of cell therapies. In fact, aborted fetal tissue has...
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Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells
The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, proliferation and...
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Comparative transcriptomic and phenotypic analysis of induced pluripotent stem cell hepatocyte-like cells and primary human hepatocytes
Primary human hepatocytes (PHHs) are used extensively for in vitro liver cultures to study hepatic functions. However, limited availability and...
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A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
The development of reliable methods for producing functional endothelial cells (ECs) is crucial for progress in vascular biology and regenerative...
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Transcription Factor-Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells
The ability to differentiate pluripotent stem cells and to generate specific cell types is a long-standing goal of regenerative medicine. This can be...
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3D Bioprinting of Induced Pluripotent Stem Cells and Disease Modeling
Patient-derived induced pluripotent stem cells (iPSCs), carrying the genetic information of the disease and capable of differentiating into...
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Generation of Cerebral Cortical Neurons from Human Pluripotent Stem Cells in 3D Culture
Human forebrain cortical neurons are essential for fundamental functions like memory and consciousness. Generation of cortical neurons from human...
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Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells
BackgroundAcute myeloid leukemia (AML) is a clonal malignant disorder which originates from a small number of leukemia-initiating cells or leukemic...
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Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA),...
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Enabling Non-invasive Tracking of Vascular Endothelial Cells Derived from Induced Pluripotent Stem Cells Using Nuclear Imaging
PurposeThe absence of clinically applicable imaging techniques for continuous monitoring of transplanted cells poses a significant obstacle to the...
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Exploiting urine-derived induced pluripotent stem cells for advancing precision medicine in cell therapy, disease modeling, and drug testing
The field of regenerative medicine has witnessed remarkable advancements with the emergence of induced pluripotent stem cells (iPSCs) derived from a...
