Search
Search Results
-
-
-
Tumor cell-derived asymmetric dimethylarginine regulates macrophage functions and polarization
BackgroundAsymmetric dimethylarginine (ADMA), which is significantly elevated in the plasma of cancer patients, is formed via intracellular recycling...
-
Automated Immunofluorescence Staining for Analysis of Mitotic Stages and Division Orientation in Brain Sections
Microcephaly often results from mitotic defects in neuronal progenitors, frequently by decreasing proliferation rates or shifting cell fates. During...
-
Cycling Within a Cell: Cell Cycle of Intracellular Kinetoplastid Parasites
Kinetoplastida forms a group of flagellated protozoan organisms with a unique organelle kinetoplastid associated with the mitochondria. They are...
-
Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors
The proper regulation of muscle stem cell (MuSC) fate by cues from the niche is essential for regeneration of skeletal muscle. How pro-regenerative...
-
Origin and Development of Cancer Stem Cells
Cancer stem cells (CSCs) have been identified in a vast number of liquid and solid tumors and have been linked to poor patient prognosis and cancer...
-
Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
BackgroundThe cell cycle of mammary stem cells must be tightly regulated to ensure normal homeostasis of the mammary gland to prevent abnormal...
-
Off the Clock: the Non-canonical Roles of Cyclin-Dependent Kinases in Neural and Glioma Stem Cell Self-Renewal
Glioma stem cells (GSCs) are thought to drive growth and therapy resistance in glioblastoma (GBM) by “hijacking” at least a subset of signaling...
-
CellTrace™ Violet Flow Cytometric Assay to Assess Cell Proliferation
CellTrace™ Violet (CTV) is a powerful tool for tracking cell proliferation by permanently binding cellular proteins and rendering the cell...
-
Mammalian Hair Cell Regeneration
In adult mammals, there is no hair cell regeneration in the cochlea and a limited capacity in the vestibular organs. Research in this area is...
-
Adult Glial Cell Proliferation and Neurogenesis
The nomenclature of stem and progenitor cells is reviewed. In the adult body, only glial cells and not neurons can proliferate. The glial cell with...
-
NANOG Stem Cell Marker and Its Role in Brain Tumor Development
The Nanog, a homeobox transcription factor that promotes the pluripotency of embryonic stem cells and inhibits cell-determinant factors. Deletion of...
-
The Possible Functions of Electromagnetic Cell Communication
Electromagnetic fields are part of the cybernetic organisation of cell dynamics. They play a major role in regulatory processes on different levels...
-
Cancer cell plasticity, stem cell factors, and therapy resistance: how are they linked?
Cellular plasticity can occur naturally in an organism and is considered an adapting mechanism during the developmental stage. However, abnormal...
-
MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Develo** mouse...
-
Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages
Accumulating evidence hints heterochromatin anchoring to the inner nuclear membrane as an upstream regulatory process of gene expression. Given that...
-
Mechanobiology of Collective Cell Migration in 3D Microenvironments
Tumor cells invade individually or in groups, mediated by mechanical interactions between cells and their surrounding matrix. These multicellular...
-
Generation of Retrogenic Mice to Investigate T Cell Development
T cells develop in the thymus from bone marrow precursors, and genetic manipulation is an indispensable tool to explore their development in vivo....
-
Gastric Stem Cell Biology and Helicobacter pylori Infection
Helicobacter pylori colonizes the human gastric mucosa and persists lifelong. An interactive network between the bacteria and host cells shapes a...