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The Gliocentric Brain

Phenotype Plasticity of the Damaged Brain

  • Book
  • © 2023

Overview

Authors:
  1. Wolfgang Walz

    1. Psychiatry, University of Saskatchewan, Saskatoon, Canada

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  • Up-to-date detailed overview of reactive gliosis

  • Approaches the topic from a biology perspective

  • Covers a full range of brain insults from normal aging to injury resulting in massive neuronal loss

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About this book

The brain is the body’s most vulnerable organ due to the defined roles of neurons within circuits. Neurons are vastly outnumbered by microglia, astrocytes, oligodendrocytes, macrophages, cells of the blood brain barrier and invading immune cells. These cells display different grades of reactivities and interactions. They integrate their responses and not only change phenotypes but can also completely reprogram after damage to protect the neuronal complexity. The interactions of these satellite cells in the healthy brain are described as well as their roles in all major brain diseases. Special emphasis is put on immune system – brain interactions and regenerative and repair processes. The gliotic response is compared with the reactions to injuries of the skin and other organs. A final chapter addresses the definition of a cell type. It concludes that cell types can no longer be regarded as defined entities over the body’s lifetime but are prone to phenotype plasticity and even complete reprograming.

Keywords

Table of contents (19 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Introduction

    • Wolfgang Walz
    Pages 1-5

  3. The Brain as an Organ

    • Wolfgang Walz
    Pages 7-27

  4. Glial Cells During the Life Cycle

    • Wolfgang Walz
    Pages 29-57

  5. Reactive Microglia and Astrocyte Phenotype Transitions: A Framework

    • Wolfgang Walz
    Pages 59-65

  6. Transition of Microglia to Reactive States

    • Wolfgang Walz
    Pages 67-76

  7. Reactive Astrocytes

    • Wolfgang Walz
    Pages 77-82

  8. Neuroinflammation

    • Wolfgang Walz
    Pages 83-89

  9. The Brain and the Immune System

    • Wolfgang Walz
    Pages 91-100

  10. Viral and Bacterial Infections

    • Wolfgang Walz
    Pages 101-112

  11. Autoimmune Diseases

    • Wolfgang Walz
    Pages 113-124

  12. Adult Glial Cell Proliferation and Neurogenesis

    • Wolfgang Walz
    Pages 125-134

  13. Glioma

    • Wolfgang Walz
    Pages 135-149

  14. Neurodegenerative Disorders

    • Wolfgang Walz
    Pages 151-166

  15. Vascular Diseases

    • Wolfgang Walz
    Pages 167-182

  16. Seizures

    • Wolfgang Walz
    Pages 183-194

  17. Traumatic Brain Injury

    • Wolfgang Walz
    Pages 195-206

  18. Major Psychiatric Disorders

    • Wolfgang Walz
    Pages 207-230

  19. Glia in Recovery Processes and Repair

    • Wolfgang Walz
    Pages 231-240

  20. Glial Phenotype Plasticity

    • Wolfgang Walz
    Pages 241-246
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Authors and Affiliations

  • Psychiatry, University of Saskatchewan, Saskatoon, Canada

    Wolfgang Walz

About the author

Wolfgang Walz is Professor Emeritus of Psychiatry at the University of Saskatchewan, Canada. His PhD thesis at the Universität Konstanz described for the first time a neurotransmitter modulation of glial ion channels. He had an active laboratory focusing on glial cell function with uninterrupted external funding for over three decades. He currently resides in Victoria, Vancouver Island, and continues to engage in scholarly activities including series editor for Neuromethods published by Springer Nature. 

Bibliographic Information

  • Book Title: The Gliocentric Brain

  • Book Subtitle: Phenotype Plasticity of the Damaged Brain

  • Authors: Wolfgang Walz

  • DOI: https://doi.org/10.1007/978-3-031-48105-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-48104-8Published: 25 January 2024

  • Softcover ISBN: 978-3-031-48107-9Due: 08 February 2025

  • eBook ISBN: 978-3-031-48105-5Published: 24 January 2024

  • Edition Number: 1

  • Number of Pages: IX, 249

  • Number of Illustrations: 17 illustrations in colour

  • Topics: Neurosciences

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