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Article
CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression
Natural killer T (NKT) cells are amongst the most important innate immune cells against hepatitis B virus (HBV) infection. Moreover, previous studies have shown that HBV infection induced TREM-1+ expression in...
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Article
Open AccessA preliminary study on the reference intervals of serum tumor marker in apparently healthy elderly population in southwestern China using real-world data
The aim is to establish and verify reference intervals (RIs) for serum tumor markers for an apparently healthy elderly population in Southwestern China using an indirect method.
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Article
Open AccessHOXA9 gene inhibits proliferation and differentiation and promotes apoptosis of bovine preadipocytes
Hox gene family is an important transcription factor that regulates cell process, and plays a role in the process of adipocytes differentiation and fat deposition. Previous transcriptome sequencing studies hav...
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Article
Estimation of genetic parameters of Holstein calf survival
Calf survival is not only an animal welfare issue but also helps to avoid huge losses in economic and genetic material due to calf mortality. Therefore, improving calf survival is essential in dairy breeding. ...
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Article
Open AccessGenetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes
After domestication, the evolution of phenotypically-varied sheep breeds has generated rich biodiversity. This wide phenotypic variation arises as a result of hidden genomic changes that range from a single nu...
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Article
Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics
Hepatocellular carcinoma (HCC) remains a significant health problem with a substantial genetic predisposition. The liver harbors the largest proportion of macrophages among all the solid organs. There is consi...
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Article
Open AccessOptimized Cas9:sgRNA delivery efficiently generates biallelic MSTN knockout sheep without affecting meat quality
CRISPR/Cas9-based genome-editing systems have been used to efficiently engineer livestock species with precise genetic alterations intended for biomedical and agricultural applications. Previously, we have suc...
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Article
Open AccessThe establishment of neuron-specific enolase reference interval for the healthy population in southwest China
To investigate and establish a reference interval (RI) of neuron-specific enolase (NSE) in southwest China’s healthy population by using the laboratory information system database. A total of 86957 periodic he...
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Article
Atomistic simulation study of favored compositions of Ni-Nb-Al metallic glasses
This study investigates the formation process of Ni-Nb-Al metallic glasses. To this end, a long-range n-body potential was constructed for the Ni-Nb-Al ternary metal system, and applied to atomistic simulations. ...
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Article
Genetic polymorphism of rs9277535 in HLA-DP associated with rheumatoid arthritis and anti-CCP production in a Chinese population
HLA-II molecules are critical in triggering human immune response, especially in activating CD4+ T cells. HLA-DP, belonging to HLA-II molecules, draws increasing attention for its role in presentation of viral...
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Article
Open AccessMitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production
Mitochondria have a central position in innate immune response via the adaptor protein MAVS in mitochondrial outer membrane to limit viral replication by inducing interferon production. Here, we reported that ...
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Article
Tβ4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics
Increasing cashmere yield is one of the vital aims of cashmere goats breeding. Compared to traditional breeding methods, transgenic technology is more efficient and the piggyBac (PB) transposon system has been...
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Article
Open AccessGenetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population
Although the SLE risk gene loci of HLA-DR and HLA-DQ within the major histocompatibility complex (MHC) region has been gradually revealed by recent Genome-Wide Association studies (GWAS), the association of HLA-D...
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Article
Open AccessMultiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep
The CRISPR/Cas9 system provides a flexible approach for genome engineering of genetic loci. Here, we successfully achieved precise gene targeting in sheep by co-injecting one-cell-stage embryos with Cas9 mRNA ...
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Article
Open AccessPathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population
Tuberculosis remains a global public health problem, and its immunopathogenesis is still poorly understood. In this study, 25 single nucleotide polymorphisms (SNPs) in the WNT pathway were evaluated in relatio...
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Article
Open AccessCorrection: Corrigendum: Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China
Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to invest...
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Article
Open AccessEpidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China
Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to invest...
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Article
Open AccessGeneration of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system
Recent advances in the study of the CRISPR/Cas9 system have provided a precise and versatile approach for genome editing in various species. However, the applicability and efficiency of this method in large an...
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Chapter and Conference Paper
Research on Automatic Layout Planning and Performance Analysis System of Production Line Based on Simulation
The automatic layout planning and performance analysis of production system is important and key technology to manufacturing enterprise to response market demand. The factors of system configuration, productio...
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Article
Surface/interface effects on dispersion relations of 2D phononic crystals with parallel nanoholes or nanofibers
Owing to the increasing ratio of surface to bulk volume, surface effects emerge in the mechanical performance of devices and materials when the characteristic size reduces to nanoscale. In this paper, the disp...
