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Article
Disturbed Th17/Treg balance in patients with rheumatoid arthritis
Proinflammatory Th17 cells and CD4+CD25+ regulatory T (Treg) cells are two newly identified T lymphocyte subsets, which have opposite effects on autoimmunity and inflammation. To assess the Th17/Treg pattern and ...
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Article
Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population
The aim of this study was to perform an association study between two single nucleotide polymorphisms (SNPs) rs2910164 G>C and rs3746444 T>C in pre-miRNA (hsa-mir-146a and hsa-mir-499) and rheumatoid arthritis...
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Article
Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus
MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE ...
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Article
Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis
The decrease of anti-inflammatory cytokine and increase of pro-inflammatory cytokine was observed in rheumatoid arthritis (RA). Interleukin-10 (IL-10), a potent anti-inflammatory cytokine, has been demonstrate...
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Article
Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
Here we show that fusion of two complementarity-determining regions (CDRs), VHCDR1 and VLCDR3, through a cognate framework region (VHFR2) yields mimetics that retain the antigen recognition of their parent molecu...
