16 Result(s)

Article

Infection with SARS-CoV-2 can cause pancreatic impairment

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes. Herein, we retrospectively analyzed pancreatic lesions...

Wei Deng, Linlin Bao, Zhiqi Song, Ling Zhang… in Signal Transduction and Targeted Therapy (2024)

Article

Efficacy and Safety of Spesolimab in Patients with Generalized Pustular Psoriasis: A Subgroup Analysis of Chinese Patients in the Effisayil 1 Trial

Generalized pustular psoriasis (GPP) is a rare and potentially life-threatening skin disease. The global Effisayil 1 study investigated the efficacy and safety of spesolimab, a humanized monoclonal antibody ta...

Tsen-Fang Tsai, Min Zheng, Yangfeng Ding, Zhiqi Song… in Dermatology and Therapy (2023)

Article

Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques

Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in esca** a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaq...

Wei Deng, Qi Lv, Fengdi Li, Jiangning Liu… in Signal Transduction and Targeted Therapy (2022)

Article

sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster

**uqin Zhang, Dan Li, Rui Sun, **nli Hu… in Signal Transduction and Targeted Therapy (2022)

Article

Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted on mink farms between minks and humans in many countries. However, the systemic pathological features of SARS-CoV-2-infected minks ar...

Zhiqi Song, Linlin Bao, Wei Deng, Jiangning Liu… in Signal Transduction and Targeted Therapy (2022)

Article

Efficacy and Safety of HLX03, an Adalimumab Biosimilar, in Patients with Moderate-to-Severe Plaque Psoriasis: A Randomized, Double-Blind, Phase III Study

Adalimumab has been used successfully in the treatment of psoriasis. The objective of the study is to compare the efficacy, safety, and immunogenicity between HLX03, an adalimumab biosimilar, and adalimumab in...

Lin Cai, Linfeng Li, Hao Cheng, Yangfeng Ding, Zhenshu Biao… in Advances in Therapy (2022)

Article

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration

SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the blood–brain barrier (BBB). Herein, SARS-C...

Ling Zhang, Li Zhou, Linlin Bao, Jiangning Liu… in Signal Transduction and Targeted Therapy (2021)

Article

Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza

Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, the influence of these viruses on disease outcome when both i...

Linlin Bao, Wei Deng, Feifei Qi, Qi Lv… in Signal Transduction and Targeted Therapy (2021)

Article

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmitted through the respiratory route, but potential extra-respiratory routes of SARS-CoV-2 transmission remain uncertain. Here we ino...

Wei Deng, Linlin Bao, Hong Gao, Zhiguang **ang, Ya** Qu… in Nature Communications (2020)

Article

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern¹. Angiotensin-converting enzym...

Linlin Bao, Wei Deng, Baoying Huang, Hong Gao, Jiangning Liu, Lili Ren, Qiang Wei… in Nature (2020)

Article

Prion protein is essential for the RE1 silencing transcription factor (REST)-dependent developmental switch in synaptic NMDA receptors

It is important that the correct amounts of GluN2 subunits are maintained, as they determine NMDAR functional properties, which are crucial to neuronal communication, synaptogenesis and cognitive function. The...

Zhiqi Song, Wei Yang, Guangyu Cheng, **angmei Zhou, Lifeng Yang… in Cell Death & Disease (2018)