3 Result(s)
within
Zac Chatterton
Proteomics
-
Article
Open AccessSingle-cell DNA methylation sequencing by combinatorial indexing and enzymatic DNA methylation conversion
DNA methylation is a critical molecular mark involved in cellular differentiation and cell-specific processes. Single-cell whole genome DNA methylation profiling methods hold great potential to resolve the DNA...
-
Article
Open AccessPaediatric leukaemia DNA methylation profiling using MBD enrichment and SOLiD sequencing on archival bone marrow smears
Acute Lymphoblastic Leukaemia (ALL) is the most common cancer in children. Over the past four decades, research has advanced the treatment of this cancer from a less than 60% chance of survival to over 85% tod...
-
Article
Open AccessReducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array
The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, ...
