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  1. Article

    Open Access

    To automate or not to automate: this is the question

    New protocols and instrumentation significantly boost the outcome of structural biology, which has resulted in significant growth in the number of deposited Protein Data Bank structures. However, even an enorm...

    M. Cymborowski, M. Klimecka, M. Chruszcz… in Journal of Structural and Functional Genom… (2010)

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  2. No Access

    Reference Work Entry At a glance

    DENZO and SCALEPACK

    This chapter uses the HKL package coordinate system to describe data algorithms and analysis. Data analysis makes specific assumptions which the collected data must...

    Z. Otwinowski, W. Minor in International Tables for Crystallography V… (2001)

  3. No Access

    Article

    Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

    Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation a...

    B. F. Luisi, W. X. Xu, Z. Otwinowski, L. P. Freedman, K. R. Yamamoto… in Nature (1991)

  4. Article

    Erratum: Crystal structure of trp represser/operator complex at atomic resolution

    Nature 335, 321-329 (1988). IN this article the present address of one of the authors was given incorrectly. Rong-guang Zhang's correct address is: Chinese Academy of Sciences, Institute of Biochemistry, Shang...

    Z. Otwinowski, R. W. Schevitz, R.-G. Zhang, C. L. Lawson, A. Joachimiak… in Nature (1988)

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  5. No Access

    Article

    Crystal structure of trp represser/operator complex at atomic resolution

    The crystal structure of the trp repressor/operator complex shows an extensive contact surface, including 24 direct and 6 solvent-mediated hydrogen bonds to the phosphate groups of the DNA. There are no direct hy...

    Z. Otwinowski, R. W. Schevitz, R.-G. Zhang, C. L. Lawson, A. Joachimiak… in Nature (1988)

  6. No Access

    Article

    The crystal structure of trp aporepressor at 1.8 Å shows how binding tryptophan enhances DNA affinity

    Comparison of the crystal structure of inactive unliganded trp aporepressor with that of trp repressor shows that binding tryptophan activates the dimer a thousandfold by moving two symmetrically-disposed flex...

    R.-g. Zhang, A. Joachimiak, C. L. Lawson, R. W. Schevitz, Z. Otwinowski… in Nature (1987)

  7. No Access

    Chapter

    trp Repressor, A Crystallographic Study of Allostery in Genetic Regulation

    The crystal structure of the E. coli trp repressor has been solved (1) and refined to 2.2 A. The two subunits (107 residues each) are related by an exact crystallographic dyad. Each subunit is composed of six hel...

    P. B. Sigler, A. Joachimiak, R. W. Schevitz, C. L. Lawson… in DNA—Ligand Interactions (1987)