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Article
Open AccessThe structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis
Heparan sulfate is a highly modified O-linked glycan that performs diverse physiological roles in animal tissues. Though quickly modified, it is initially synthesised as a polysaccharide of alternating β-d-glucur...
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Article
Complementing structural information of modular proteins with small angle neutron scattering and contrast variation
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Article
Complementing structural information of modular proteins with small angle neutron scattering and contrast variation
Many macromolecules in the cell function by forming multi-component assemblies. We have applied the technique of small angle neutron scattering to study a nucleic acid–protein complex and a multi-protein compl...
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Article
Structure, mechanism and catalytic duality of thiamine-dependent enzymes
Thiamine is an essential cofactor that is required for processes of general metabolism amongst all organisms, and it is likely to have played a role in the earliest stages of the evolution of life. Here, we re...
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Understanding Biological Machines Using Household Items: Some Insightful Constructions from the Calladine Workshop
Recent crystallographic studies have revealed a novel protein architecture in which twelve α-helices form a cylindrical bundle. The geometrical principles of this architecture, referred to as the α-helical bar...
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Article
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation a...
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Article
Erratum: Crystal structure of trp represser/operator complex at atomic resolution
Nature 335, 321-329 (1988). IN this article the present address of one of the authors was given incorrectly. Rong-guang Zhang's correct address is: Chinese Academy of Sciences, Institute of Biochemistry, Shang...
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Article
Crystal structure of trp represser/operator complex at atomic resolution
The crystal structure of the trp repressor/operator complex shows an extensive contact surface, including 24 direct and 6 solvent-mediated hydrogen bonds to the phosphate groups of the DNA. There are no direct hy...
