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Article
Open AccessRAISING is a high-performance method for identifying random transgene integration sites
Both natural viral infections and therapeutic interventions using viral vectors pose significant risks of malignant transformation. Monitoring for clonal expansion of infected cells is important for detecting ...
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Article
A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo
Approximately 10–20 million of Human T-cell leukemia virus type-1 (HTLV-1)-infected carriers have been previously reported, and approximately 5% of these carriers develop adult T-cell leukemia/lymphoma (ATL) w...
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Article
Open AccessCloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice
Although the CRISPR/Cas system has enabled one-step generation of knockout mice, low success rates of cassette knock-in limit its application range. Here we show that cloning-free, direct nuclear delivery of C...
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Article
Open AccessDevelopment of detection method for novel fusion gene using GeneChip exon array
Fusion genes have been recognized to play key roles in oncogenesis. Though, many techniques have been developed for genome-wide analysis of fusion genes, a more efficient method is desired.
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Chapter
Post-Corrosion and Metallurgical Analyses of Sodium Pi** Materials Operated for 100,000 Hours
For liquid metal (sodium) cooled fast reactor systems, the effects of sodium environment on the corrosion and the mechanical strength properties of structural materials have to be evaluated to maintain the mat...
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Chapter
High-Cycle Fatigue Behaviour of Alloy 718 in Liquid Sodium
In the vicinity of the core outlet of a fast breeder reactor, thermal stri** arises from the coolant temperature difference between the outlet of the fuel assemblies and the control rod assemblies, and cause...
