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  1. No Access

    Article

    Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis

    Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we...

    Naganori Nao, Tomohiro Okagawa, Naomi Nojiri, Satoru Konnai… in Archives of Virology (2024)

  2. Article

    Open Access

    RAISING is a high-performance method for identifying random transgene integration sites

    Both natural viral infections and therapeutic interventions using viral vectors pose significant risks of malignant transformation. Monitoring for clonal expansion of infected cells is important for detecting ...

    Yusaku Wada, Tomoo Sato, Hiroo Hasegawa, Takahiro Matsudaira… in Communications Biology (2022)

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  3. No Access

    Article

    A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo

    Approximately 10–20 million of Human T-cell leukemia virus type-1 (HTLV-1)-infected carriers have been previously reported, and approximately 5% of these carriers develop adult T-cell leukemia/lymphoma (ATL) w...

    Masumichi Saito, Hiroo Hasegawa, Shunsuke Yamauchi… in International Journal of Hematology (2020)

  4. Article

    Open Access

    Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo

    Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, there are no therapies to prevent ATL development in high-risk asymptomatic carriers. To develop a thera...

    Masateru Hiyoshi, Kazu Okuma, Seiji Tateyama, Kazuya Takizawa… in Retrovirology (2015)

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  5. No Access

    Article

    The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

    The molecular control of germinal center selection is still being determined. Dalla-Favera and colleagues show that the cell-cycle regulator c-Myc is essential for B cell selection and reentry into the germina...

    David Dominguez-Sola, Gabriel D Victora, Carol Y Ying, Ryan T Phan… in Nature Immunology (2012)

  6. No Access

    Article

    Genome-wide identification of post-translational modulators of transcription factor activity in human B cells

    Modulatory proteins ensure that transcription factors are active when and where they should be. Wang et al. describe an algorithm for identifying modulators from a compendium of gene expression profiles and exper...

    Kai Wang, Masumichi Saito, Brygida C Bisikirska, Mariano J Alvarez… in Nature Biotechnology (2009)

  7. No Access

    Article

    Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells

    Antigen-specific B cells are selected in germinal centers, the structure in which these cells proliferate while accomplishing genome-remodeling processes such as class-switch recombination and somatic hypermut...

    Ryan T Phan, Masumichi Saito, Yukiko Kitagawa, Anthony R Means… in Nature Immunology (2007)

  8. No Access

    Article

    BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

    The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center formation and has been linked to lymphomagenesis. BCL6 functions by directly binding to specific DNA sequences and ...

    Ryan T Phan, Masumichi Saito, Katia Basso, Huifeng Niu… in Nature Immunology (2005)