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Article
Open AccessPlatelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis
Osteosarcoma is the most common primary malignant bone cancer, with high rates of pulmonary metastasis. Osteosarcoma patients with pulmonary metastasis have worse prognosis than those with localized disease, l...
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Article
Open AccessDevelopment of detection method for novel fusion gene using GeneChip exon array
Fusion genes have been recognized to play key roles in oncogenesis. Though, many techniques have been developed for genome-wide analysis of fusion genes, a more efficient method is desired.
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Article
Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein – Barr virus
The characteristics of B-lymphoblastoid cell strains transformed by Epstein – Barr virus (EBV) from normal individuals and Werner's syndrome (WRN) patients were compared. We continuously passaged cell strains ...
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Article
Mutation and haplotype analyses of the Werner’s syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population
The correlation between mutations in the Werner’s syndrome (WRN) gene and the haplotypes of surrounding markers was studied in Japanese patients. We have elucidated the genomic structure of WRN helicase, and ...
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Article
Analysis of helicase gene mutations in Japanese Werner’s syndrome patients
The profile of helicase gene mutations was studied in 89 Japanese Werner’s syndrome (WRN) patients by examining the previously described mutations 1– 4 as well as a new mutation found during this study, desig...
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Article
Develo** a Method for Wide-Control of the Self-Bias and its Adoption to Ion-Damage Control
We have developed a technique which enables us to reduce the self-bias voltage without introducing any substantial disturbance to the main plasma. This approach is based on decreasing the floating potential of...
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Article
Diatomic interactions in momentum space. The 2pπ u and 3dπ g states of H 2 + system
The recently proposed method of momentum electron density for interatomic interactions is applied to the two π states of the H 2 + system. The processes of the...
