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Article
Cascaded signal amplification strategy for ultra-specific, ultra-sensitive, and visual detection of Shigella flexneri
Pathogen infections including Shigella flexneri have posed a significant threat to human health for numerous years. Although culturing and qPCR were the gold standards for pathogen detection, time-consuming and i...
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Article
Open AccessMi-2β promotes immune evasion in melanoma by activating EZH2 methylation
Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit. Converting resistant tumors to immunotherapy sens...
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Article
Open AccessO-GlcNAc of STING mediates antiviral innate immunity
O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylation was reported to participate in antivirus response. Stimulator of interferon genes (S...
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Article
Open AccessEnhancing cold resistance in Banana (Musa spp.) through EMS-induced mutagenesis, L-Hyp pressure selection: phenotypic alterations, biomass composition, and transcriptomic insights
The cultivation of bananas encounters substantial obstacles, particularly due to the detrimental effects of cold stress on their growth and productivity. A potential remedy that has gained attention is the uti...
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Article
Influencing mechanisms of tartaric acid on adsorption and degradation of tetracycline on goethite: insight from solid and liquid aspects
The interactions between organic pollutants and iron minerals play an important role in their environmental fate. In this study, the effects of low-molecular-weight organic acids (LMWOAs) on the adsorption and...
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Article
Combined function of glycerol monolaurate/phytol and carnauba wax for improving the hydrophobic and anti-mildew properties of bamboo
Bamboo is highly susceptible to mold infection owing to the presence of large number of holes and rich nutrients, resulting in huge economic losses. Chemical bacteriostasis plays an effective role in mildew pr...
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Article
Open AccessHidden prevalence of deletion-inversion bi-alleles in CRISPR-mediated deletions of tandemly arrayed genes in plants
Tandemly arrayed genes (TAGs) with functional redundancy and chromosomal linkage constitute 14 ~ 35% in sequenced plant genomes. The multiplex CRISPR system is the tool of choice for creating targeted TAG dele...
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Article
Open AccessFaster sorting algorithms discovered using deep reinforcement learning
Fundamental algorithms such as sorting or hashing are used trillions of times on any given day1. As demand for computation grows, it has become critical for these algorithms to be as performant as possible. Where...
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Article
Mixed invasive ductal lobular carcinoma is clinically and pathologically more similar to invasive lobular than ductal carcinoma
Mixed invasive ductal lobular carcinoma (mDLC) remains a poorly understood subtype of breast cancer composed of coexisting ductal and lobular components.
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Article
Open AccessInduction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34+ cells
The most significant cause of treatment failure in chronic myeloid leukemia (CML) is a persistent population of minimal residual cells. Emerging evidences showed that methylation of SHP-1 contributed to Imatin...
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Article
Preliminary analysis on the formation mechanism of the unexpected catastrophic Qijiaba landslide in a tectonically non-active hilly area of China
Landslides which occur at unexpected locations and times, and which have unrecognizable risk areas, often cause mass casualties. Despite there being few preceding landslides in the same season, the catastrophi...
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Article
Uplift history of the Northern Tianshan constrained from the inversion of river profiles
Knowledge of the uplift history and evolution process of the Cenozoic Tianshan Mountains (TMs) provides important insights for inland Asia geodynamic models and paleoclimate reconstructions. Although uplift ra...
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Mechanisms of Alcohol-Related Liver Cirrhosis
Liver cirrhosis-induced portal hypertension is a major cause for mortality in chronic liver diseases, including alcohol-related liver disease. Anatomically, liver cirrhosis is presented as septa separating hep...
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Article
Plasma membrane-nucleo-cytoplasmic coordination of a receptor-like cytoplasmic kinase promotes EDS1-dependent plant immunity
Plants use cell-surface immune receptors to recognize pathogen-specific patterns to evoke basal immunity. ENHANCED DISEASE SUSCEPTIBILITY (EDS1) is known to be crucial for plant basal immunity, whereas its act...
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Article
TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway
The dynamics of mitochondrial biogenesis regulation is critical in maintaining cellular homeostasis for immune regulation and tumor prevention. Here, we report that mitochondrial biogenesis disruption through ...
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Article
Open AccessGPI-anchored FGF directs cytoneme-mediated bidirectional contacts to regulate its tissue-specific dispersion
How signaling proteins generate a multitude of information to organize tissue patterns is critical to understanding morphogenesis. In Drosophila, FGF produced in wing-disc cells regulates the development of the d...
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Article
Tool wear prediction under missing data through prioritization of sensor combinations
It is significant to ensure stable machining quality that accurately monitors the tool wear. Sensor signals are mainly used to predict tool wear. Therefore, complete sensor signals are crucial for tool wear pr...
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Article
Open AccessIncreased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway
Mitochondrial dynamics homeostasis is important for cell metabolism, growth, proliferation, and immune responses. The critical GTPase for mitochondrial fission, Drp1 is frequently upregulated in many cancers a...
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Article
Open AccessIRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3
Although interferon regulatory factor 2 (IRF2) was reported to stimulate virus replication by suppressing the type I interferon signaling pathway, because cell cycle arrest was found to promote viral replicati...
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Article
Open AccessIvermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway
Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is impe...
