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Article
Open AccessMultimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity
Primates exhibit complex brain structures that augment cognitive function. The neocortex fulfills high-cognitive functions through billions of connected neurons. These neurons have distinct transcriptomic, mor...
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Article
Open AccessA primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson’s disease
The degenerative process in Parkinson’s disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in neuronal susceptibility warrants an amena...
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Article
Open AccessDynamic changes in macrophage morphology during the progression of choroidal neovascularization in a laser-induced choroidal neovascularization mouse model
Neovascular age-related macular degeneration (AMD) is responsible for the majority of severe vision loss cases and is mainly caused by choroidal neovascularization (CNV). This condition persists or recurs in a...
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Article
Efficacy and safety of immune checkpoint inhibitors in post-TKI NSCLC patients harboring EGFR mutations
Immune checkpoint inhibitors (ICIs) have been validated in epidermal growth factor receptor (EGFR) wild-type advanced non-small cell lung cancer (NSCLC) patients. However, there exists no evidence regarding NS...
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Article
Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures
The low number of neural progenitor cells (NPCs) present in the adult and aged primate brains represents a challenge for generating high-yield and viable in vitro cultures of primary brain cells. Here we repor...
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Article
Open AccessIdentification of visual cortex cell types and species differences using single-cell RNA sequencing
The primate neocortex exerts high cognitive ability and strong information processing capacity. Here, we establish a single-cell RNA sequencing dataset of 133,454 macaque visual cortical cells. It covers major...
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Article
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations
The extent to which neurogenesis occurs in adult primates remains controversial. In this study, using an optimized single-cell RNA sequencing pipeline, we profiled 207,785 cells from the adult macaque hippocam...
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Article
Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?
To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or ser...
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Article
Open AccessIvermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway
Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is impe...
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Article
Controlled morphologies and hydration process of hydratable alumina by using citric acid
Hydration mechanisms of hydratable alumina (HA) in citric acid at different pH are investigated in this study, aiming to improve rapid hydration process and massive hydration heat. By adding citric acid to adj...
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Article
Open AccessDisruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice
Atg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here we show that genetic ablation of Atg7 in outer hair cells (OHCs) in mice caused stereocilium damage, somatic electromoti...
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Article
Open AccessNigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice
Nigella A, also named Sieboldianoside A, has been extracted from many kinds of Traditional Chinese Medicine (TCM), such as Nigella glandulifera, Stauntonia chinensis DC., and the leaves of Acanthopanax sieboldian...
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Article
Establishment and application of a multiplex PCR assay for detection of Rhizoctonia cerealis, Bipolaris sorokiniana, and Fusarium spp. in winter wheat
Rhizoctonia cerealis, Bipolaris sorokiniana, and Fusarium spp. are three wheat-damaging soil-borne fungal pathogens causing sharp eyespot, common root rot, and crown rot, respectively. This study aimed to develop...
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Article
Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro
Gentamicin, one of the most widely used aminoglycoside antibiotics, is known to have toxic effects on the inner ear. Taken up by cochlear hair cells and spiral ganglion neurons (SGNs), gentamicin induces the a...
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Article
Postoperative chemotherapy as adjuvant treatment for endometrioid adenocarcinoma: early stage vs late stage
Adjuvant chemotherapy treatment for different endometrial cancer stages is still debated. We aimed to evaluate the outcome of early (FIGO I–II) vs late stage (FIGO III–IV) endometrial cancer in an institutiona...
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Article
Efficient production of d-1,2,4-butanetriol from d-xylose by engineered Escherichia coli whole-cell biocatalysts
We have developed a whole-cell bioconversion system for the production of d-1,2,4-butanetriol (BT) from renewable biomass. A plasmid pETduet-xylB-yjhG-T7-adhP-T7-mdlC was constructed and transformed to Escherichi...
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Article
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway
Chronic constipation is often accompanied by emotional disorders such as depression and anxiety. The aim of this study was to determine whether administration of a multispecies probiotic can decrease depressiv...
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Chapter and Conference Paper
Space-Borne Integrated Design Analysis of Remote Sensing Camera on Geosynchronous Orbit
This Paper presents a space-borne integrated design analysis of remote sensing camera on Geosynchronous orbit. Considering the engineering practice, a typical structure forming method is given out which is app...
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Article
Open AccessEnantio-alteration of gene transcription associated with bioconcentration in adult zebrafish (Danio rerio) exposed to chiral PCB149
Enantioselective enrichment of chiral PCB149 (2,2’,3,4’,5’,6-hexachlorobiphenyl) was analysed in adult zebrafish (Danio rerio) exposed to the racemate, (−)-PCB149 and (+)-PCB149. Greater enrichment of (−)-PCB149 ...
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Article
Effects of Added Al Powder on the Properties of Sialon-ZrN Composites Fabricated by Aluminothermic Reduction and Nitridation
Sialon-ZrN composites were synthesized from zircon and aluminium via an aluminothermic reduction and nitridation process. The effects of extra Al powder on the product phase compositions and morphologies were ...
