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Article
Open AccessDynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication
The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are targets for cancer therapy. It is important to determine if the...
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Article
Open AccessCholesterol modulates type I/II TGF-β receptor complexes and alters the balance between Smad and Akt signaling in hepatocytes
Cholesterol mediates membrane compartmentalization, affecting signaling via differential distribution of receptors and signaling mediators. While excessive cholesterol and aberrant transforming growth factor-β (T...
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Article
Open AccessTolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation
The human liver has a remarkable capacity to regenerate and thus compensate over decades for fibrosis caused by toxic chemicals, drugs, alcohol, or malnutrition. To date, no protective mechanisms have been ide...
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Mechanisms of Alcohol-Related Liver Cirrhosis
Liver cirrhosis-induced portal hypertension is a major cause for mortality in chronic liver diseases, including alcohol-related liver disease. Anatomically, liver cirrhosis is presented as septa separating hep...
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Article
Open AccessMesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β
Post-surgery liver failure is a serious complication for patients after extended partial hepatectomies (ePHx). Previously, we demonstrated in the pig model that transplantation of mesenchymal stromal cells (MS...
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Article
Open AccessDysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is...
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Article
Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl4-induced acute liver injury
Acute liver injury results from the complex interactions of various pathological processes. The TGF-β superfamily plays a crucial role in orchestrating fibrogenic response. In contrast to TGF-β1, a role of TGF...
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Article
Open AccessHepatocyte caveolin-1 modulates metabolic gene profiles and functions in non-alcoholic fatty liver disease
Caveolin-1 (CAV1) is a crucial regulator of lipid accumulation and metabolism. Previous studies have shown that global Cav1 deficiency affects lipid metabolism and hepatic steatosis. We aimed to analyze the conse...
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Article
An inverse agonist of estrogen-related receptor γ regulates 2-arachidonoylglycerol synthesis by modulating diacylglycerol lipase expression in alcohol-intoxicated mice
Chronic alcohol feeding increases the levels of 2-arachidonoylglycerol (2-AG) in the liver, which activates hepatic cannabinoid receptor type 1 (CB1R), leading to oxidative liver injury. 2-AG biosynthesis is c...
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Article
Correction to: Human skin-derived ABCB5+ stem cell injection improves liver disease parameters in Mdr2KO mice
We wish to submit a corrigendum to the above-mentioned article. Thank you very much for consideration and publication.
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Article
Human skin-derived ABCB5+ stem cell injection improves liver disease parameters in Mdr2KO mice
Although liver transplantation is a potential effective cure for patients with end-stage liver diseases, this strategy has several drawbacks including high cost, long waiting list, and limited availability of ...
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Article
Open AccessCorrection to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
In the publication of this article (1), there is an error in Fig. 5b. This has now been updated in the original article (1).
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Article
Open AccessSOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
Sex-determining region Y-box (SRY-box) containing gene 9 (SOX9) expression confers cancer stem cell features. However, SOX9 function in intrahepatic cholangiocarcinoma (iCCA) is unknown. This study investigate...
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Article
Open AccessSmall heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation
Recently, we reported that orphan nuclear receptor small heterodimer partner (SHP) is involved in neutrophil recruitment through the regulation of C-X-C motif chemokine ligand 2 (CXCL2) expression in a concana...
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Article
Open AccessFocused scores enable reliable discrimination of small differences in steatosis
Automated image analysis enables quantitative measurement of steatosis in histological images. However, spatial heterogeneity of steatosis can make quantitative steatosis scores unreliable. To improve the reli...
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Article
Open AccessLiver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of ...
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Article
Inverse agonist of ERRγ reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver
Upon liver intoxication with malnutrition or high-fat diet feeding, fibrinogen is synthesized by hepatocytes and secreted into the blood in human and mouse. Its primary function is to occlude blood vessels upo...
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Article
MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis
MicroRNA (miRNA)-mediated gene regulation contributes to liver pathophysiology, including hepatic stellate cell (HSC) activation and fibrosis progression. Here, we investigated the role of miR-942 in human liv...
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Article
Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
Tamoxifen (TAM) is commonly used for cell type specific Cre recombinase-induced gene inactivation and in cell fate tracing studies. Inducing a gene knockout by TAM and using non-TAM exposed mice as controls le...
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Article
Galunisertib modifies the liver fibrotic composition in the Abcb4Ko mouse model
Transforming growth factor (TGF)-β stimulates extracellular matrix (ECM) deposition during development of liver fibrosis and cirrhosis, the most important risk factor for the onset of hepatocellular carcinoma....
