11 Result(s)

Article

Identification of oleic acid as an endogenous ligand of GPR3

Although GPR3 plays pivotal roles in both the nervous system and metabolic processes, such as cold-induced thermogenesis, its endogenous ligand remains elusive. Here, by combining structural approach (includin...

Yangjie **ong, Zhenmei Xu, **nzhi Li, Yuqin Wang, **g Zhao, Na Wang… in Cell Research (2024)

Article

Structural basis of Sphingosine-1-phosphate transport via human SPNS2

Yaning Duan, Nancy C. P. Leong, **g Zhao, Yu Zhang, Dat T. Nguyen… in Cell Research (2024)

Article

Crystal structure of heliorhodopsin 48C12

Yang Lu, X. Edward Zhou, **ang Gao, Na Wang, Ruixue **a, Zhenmei Xu… in Cell Research (2020)

Article

Molecular assembly of rhodopsin with G protein-coupled receptor kinases

G protein-coupled receptor kinases (GRKs) play pivotal roles in desensitizing GPCR signaling but little is known about how GRKs recognize and phosphorylate GPCRs due to the technical difficulties in detecting ...

Yuanzheng He, **ang Gao, Devrishi Goswami, Li Hou, Kuntal Pal, Yanting Yin… in Cell Research (2017)

Article

Erratum: Discovery of a highly potent glucocorticoid for asthma treatment

Correction to: Cell Discovery (2015) 1, 15035; doi:10.1038/celldisc.2015.35; published online 15 December 2015 In the initial published version of this article, an error was made when we drew the chemical stru...

Yuanzheng He, **g**g Shi, Wei Yi, **n Ren, **ang Gao, Jianshuang Li… in Cell Discovery (2016)

Article

Discovery of a highly potent glucocorticoid for asthma treatment

Glucocorticoids are the most effective treatment for asthma. However, their clinical applications are limited by low efficacy in severe asthma and by undesired side effects associated with high dose or prolong...

Yuanzheng He, **g**g Shi, Wei Yi, **n Ren, **ang Gao, Jianshuang Li… in Cell Discovery (2015)

Article

Structures and mechanism for the design of highly potent glucocorticoids

The evolution of glucocorticoid drugs was driven by the demand of lowering the unwanted side effects, while kee** the beneficial anti-inflammatory effects. Potency is an important aspect of this evolution as...

Yuanzheng He, Wei Yi, Kelly Suino-Powell, X Edward Zhou, W David Tolbert… in Cell Research (2014)

Article

Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14

Li-Hua Zhao, X Edward Zhou, Zhong-Shan Wu, Wei Yi, Yong Xu, Suling Li… in Cell Research (2013)