-
Article
Open AccessTopoisomerase I is an evolutionarily conserved key regulator for satellite DNA transcription
RNA Polymerase (RNAP) II transcription on non-coding repetitive satellite DNAs plays an important role in chromosome segregation, but a little is known about the regulation of satellite transcription. We here ...
-
Article
Managing faba bean wilt disease through intercrop** with wheat and reasonable nitrogen application: enhancing nutrient absorption and biochemical resistance in faba beans
Faba bean wilt disease is a key factor limiting its production. Intercrop** of faba bean with wheat has been adopted as a prevalent strategy to mitigate this disease. Nitrogen fertilizer improves faba bean y...
-
Article
Open AccessAn at-leg pellet and associated Penicillium sp. provide multiple protections to mealybugs
Beneficial fungi are well known for their contribution to insects’ adaptation to diverse habitats. However, where insect-associated fungi reside and the underlying mechanisms of insect-fungi interaction are no...
-
Article
Mechanism of benzoxazinoids affecting the growth and development of Fusarium oxysporum f. sp. fabae
Continuous crop** of faba bean (Vicia faba L.) has led to a high incidence of wilt disease. The implementation of an intercrop** system involving wheat and faba bean can effectively control the propagation of...
-
Article
Benzoxazinoids secreted by wheat root weaken the pathogenicity of Fusarium oxysporum f. sp. fabae by inhibiting linoleic acid and nucleotide metabolisms
The regulatory action of BXs secreted by wheat on the pathogenicity of FOF causing Fusarium wilt in faba bean were analyzed. DIMBOA and MBOA weakened the pathogenicity of FOF.
-
Article
Open AccessUnexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa
Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gen...
-
Article
Optimal N Application Improves Interspecific Relationship, Productivity and N Utilization in Wheat/Faba Bean Intercrop**
We assessed the effects of various N levels on interspecific interaction and faba bean N utilization and yield in wheat/faba bean intercrop** system. The field experiments involved three crop** systems (fa...
-
Article
Open AccessProteomic analysis of the faba bean-wheat intercrop** system in controlling the occurrence of faba bean fusarium wilt due to stress caused by Fusarium oxysporum f. sp. fabae and benzoic acid
In faba bean, continuous crop** severely affects plant growth and increases the incidence of fusarium wilt due to the accumulation of pathogens and autotoxic substances. The intercrop** of faba bean and wh...
-
Article
Open AccessEvaluation of the MC3R gene pertaining to body weight and height regulation and puberty development
Recent studies reported an impact of the melanocortin 3 receptor (MC3R) on the regulation of body weight, linear growth and puberty timing. Previously, allele p.44Ile of a frequent non-synonymous variant (NSV)...
-
Article
Open AccessEvidence for correlations between BMI-associated SNPs and circRNAs
Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment o...
-
Article
Open AccessPTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation
Genetic factors are relevant for both eating disorders and body weight regulation. A recent genome-wide association study (GWAS) for anorexia nervosa (AN) detected eight genome-wide significant chromosomal loc...
-
Article
Correction: GRK3 deficiency elicits brain immune activation and psychosis
-
Article
Open AccessGRK3 deficiency elicits brain immune activation and psychosis
The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein levels, of GRK3 are reduced i...
-
Article
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery
Cytokines released after T cell activation improve the efficacy of T cell therapies in mice.
-
Article
Open AccessT cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because attempts to target tumors directly have yielded limited b...
-
Article
Open AccessT lymphocyte engineering with cytokine nanogels for enhanced cancer immunotherapy
-
Article
Structure-based programming of lymph-node targeting in molecular vaccines
An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes.
