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Article
ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer
Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) is treated with ALK tyrosine kinase inhibitors (TKIs), but the lack of activity of immune checkpoint inhibitors (ICIs) is poorly unde...
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Article
Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines
The formulations of peptide-based antitumour vaccines being tested in clinical studies are generally associated with weak potency. Here, we show that pharmacokinetically tuning the responses of peptide vaccine...
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Article
Open AccessErratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry
Nature Communications 8 Article number: 14069 (2017); Published 17 January 2017; Updated 14 August 2017 In Fig. 4d of this Article, the schematic was incorrectly illustrated with one SIINFEKL peptide detached ...
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Article
Open AccessHigh-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry
Inorganic nanoparticles (NPs) are studied as drug carriers, radiosensitizers and imaging agents, and characterizing nanoparticle biodistribution is essential for evaluating their efficacy and safety. Tracking ...
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Article
Open AccessTargeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to dela...
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Article
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
An immunotherapy consisting of a tumor-antigen targeting antibody, PD-1 blocking antibody, extended half-life recombinant IL-2 and a lymph-node-targeted T cell vaccine mobilized innate and adaptive immunity an...
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Article
Structure-based programming of lymph-node targeting in molecular vaccines
An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes.
