-
Article
Open AccessBi-directional neuro-immune dysfunction after chronic experimental brain injury
It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neur...
-
Article
Open AccessAuthor Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
-
Article
Open AccessTrimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
Age-associated changes in the T cell compartment are well described. However, limitations of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq (RNA sequencing) and CITE-seq ...
-
Article
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
An immunotherapy consisting of a tumor-antigen targeting antibody, PD-1 blocking antibody, extended half-life recombinant IL-2 and a lymph-node-targeted T cell vaccine mobilized innate and adaptive immunity an...
-
Article
Open AccessExtraction and analysis of signatures from the Gene Expression Omnibus by the crowd
Gene expression data are accumulating exponentially in public repositories. Reanalysis and integration of themed collections from these studies may provide new insights, but requires further human curation. He...
-
Article
Structure-based programming of lymph-node targeting in molecular vaccines
An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes.
-
Article
Engineering synthetic vaccines using cues from natural immunity
The clinical application of vaccines has expanded from infectious diseases to cancer, enhancing our vision of how the immune system can be used to prevent and treat disease. This Review highlights recent devel...
