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Article
Liver Iron Overload Drives COVID-19 Mortality: a Two-Sample Mendelian Randomization Study
Iron overload has been associated with an increased risk of COVID-19 severity and mortality in observational studies, but it remains unclear whether these associations represent causal effects. We performed a ...
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Article
Orexin B protects dopaminergic neurons from 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity associated with reduced extracellular signal-regulated kinase phosphorylation
The loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) is a major pathological hallmark of Parkinson’s disease (PD). Orexin B (OXB) has been reported to promote the growth of DA neu...
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Article
An epigenome-wide association study of waist circumference in Chinese monozygotic twins
Central obesity poses significant health risks because it increases susceptibility to multiple chronic diseases. Epigenetic features such as DNA methylation may be associated with specific obesity traits, whic...
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Article
Open AccessDiphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects
Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), a key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defect...
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Article
Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity
Both genetic and epigenetic variations of GLP1R influence the development and progression of obesity. However, the underlying mechanism remains elusive. This study aims to explore the mediation roles of obesity-r...
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Article
Open AccessContactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a role in its function. However, key en...
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Article
Open AccessThe moderated-mediation role of risk perception and intolerance of uncertainty in the association between residual symptoms and psychological distress: a cross-sectional study after COVID-19 policy lifted in China
A considerable number of individuals infected with COVID-19 experience residual symptoms after the acute phase. However, the correlation between residual symptoms and psychological distress and underlying mech...
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Article
Open AccessPerceived risk of COVID-19 hurts mental health: the mediating role of fear of COVID-19 and the moderating role of resilience
Depression and anxiety have been found prevalent during all phases of the COVID-19 pandemic. In late December 2022, almost all COVID-19 control measures were lifted in China, leading to a surge in COVID-19 inf...
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Article
Open AccessA framework to assess multi-hazard physical climate risk for power generation projects from publicly-accessible sources
Demand for information about physical climate risk is growing, particularly for the power generation sector, given its size and pronounced exposure to climate hazards. However, quantifying physical climate ris...
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Article
Open AccessPerceived parenting styles and incidence of major depressive disorder: results from a 6985 freshmen cohort study
Even though a fair amount of studies focus on depression among college students, the effect of perceived parenting styles on the incidence of major depressive disorder (MDD) among representative freshmen in Ch...
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Article
Open AccessUpregulation of carbonic anhydrase 1 beneficial for depressive disorder
Carbonic Anhydrase 1 (CAR1) is a zinc-metalloenzyme that catalyzes the hydration of carbon dioxide, and the alteration of CAR1 has been implicated in neuropsychiatric disorders. However, the mechanism underlyi...
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Article
Open AccessACx-projecting cholinergic neurons in the NB influence the BLA ensembles to modulate the discrimination of auditory fear memory
Animals need discriminating auditory fear memory (DAFM) to survive, but the related neural circuits of DAFM remain largely unknown. Our study shows that DAFM depends on acetylcholine (ACh) signal in the audito...
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Article
Open AccessEpigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure
Hypertension is a crucial risk factor for develo** cardiovascular disease and reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially related to systolic blood pressure (SBP)...
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Article
Open AccessCOVID-19 vaccine uptake and vaccine hesitancy in rural-to-urban migrant workers at the first round of COVID-19 vaccination in China
Migration can be linked to the transmission of COVID-19. COVID-19 vaccine uptake and hesitancy among rural-to-urban migrant workers in China, the largest group of internal migrants in the world, has not been c...
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Article
Open AccessClusterin transduces Alzheimer-risk signals to amyloidogenesis
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Article
Nomogram for predicting the 12-year risk of ADL disability among older adults
Previous studies have identified plenty of risk factors for activities of daily living (ADL). However, there are no reliable and widely available prediction models for ADL disability up to now. This study aime...
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Reference Work Entry In depth
Source/Sink Characteristics of SVOCs
Semivolatile organic compounds (SVOCs) are ubiquitous and persistent in indoor environments. It is important to understand the mechanisms governing their emission, sorption, and transport. This article reviews...
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Living Reference Work Entry In depth
Source/Sink Characteristics of SVOCs
Semivolatile organic compounds (SVOCs) are ubiquitous and persistent in indoor environments. It is important to understand the mechanisms governing their emission, sorption, and transport. This article reviews...
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Article
Open AccessEstablishment of a nomogram model to predict macrosomia in pregnant women with gestational diabetes mellitus
To establish a nomogram model to predict the risk of macrosomia in pregnant women with gestational diabetes mellitus in China.
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Article
Open AccessGenome-wide DNA methylation and gene expression analyses in monozygotic twins identify potential biomarkers of depression
Depression is currently the leading cause of disability around the world. We conducted an epigenome-wide association study (EWAS) in a sample of 58 depression score-discordant monozygotic twin pairs, aiming to...
