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Article
Open AccessDiphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects
Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), a key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defect...
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Article
Classification of ice and water in the Arctic using radar altimeter and microwave radiometer data from HY-2B satellite
Several Chinese marine satellites have been launched in recent years. Monitoring sea ice and the ocean in the Arctic is of great importance for climate research. Sea ice in the Arctic has changed rapidly durin...
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Article
Open AccessGonadotropin releasing hormone (GnRH): a hormone therapy boosts cognition in Down syndrome and dementia
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Article
Summer phytoplankton blooms off the Somali coast in the South-western Arabian Sea from remote sensing observations
Summer phytoplankton blooms appear frequently off the Somali coast in the southwestern Arabian Sea (AS), where strong reversal monsoon and summer upwelling is prevailing. Distinct high chlorophyll-a (Chl-a) conce...
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Article
Open AccessDeep soil water storage varies with vegetation type and rainfall amount in the Loess Plateau of China
Soil-water storage in a deep soil layer (SWSD), defined as the layer where soil water is not sensitive to daily evapotranspiration and regular rainfall events, functions as a soil reservoir in China’s Loess Pl...
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Article
Open AccessRare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects
Heterotaxy (Htx) syndrome comprises a class of congenital disorders resulting from malformations in left-right body patterning. Approximately 90% of patients with heterotaxy have serious congenital heart disea...
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Article
Duplication and Deletion of 22q11 Associated with Anomalous Pulmonary Venous Connection
Anomalous pulmonary venous connection (APVC) is an uncommon congenital anomaly in which pulmonary venous blood flows directly into the right side of the heart or into the systemic veins. To identify whether th...
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Article
Open AccessA 3 base pair deletion in TBX1 leads to reduced protein expression and transcriptional activity
Transcription factor TBX1 plays a pivotal role in heart development and has been implicated in 22q11.2 deletion syndrome. The structure of this protein has been elucidated, and several mutations have been iden...
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Article
Open AccessThe association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer
To investigate the relationship between P-glycoprotein (Pgp), glutathione S-transferase π (GST-π) and topoisomerase II (Topo II) expression and human gastric cancer chemoresistance in vitro.
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Article
Bifurcation of Pacific North Equatorial Current at the surface
The grid altimetry data between 1993 and 2006 near the Philippines were analyzed by the method of Empirical Orthogonal Function (EOF) to study the variation of bifurcation of the North Equatorial Current at th...
