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  1. No Access

    Article

    Sleep-mediated regulation of reward circuits: implications in substance use disorders

    Our modern society suffers from both pervasive sleep loss and substance abuse—what may be the indications for sleep on substance use disorders (SUDs), and could sleep contribute to the individual variations in...

    Rong Guo, Dylan Thomas Vaughan, Ana Lourdes Almeida Rojo… in Neuropsychopharmacology (2023)

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    Article

    Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens

    Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and prioritizes different emotional and mot...

    Alexander K. Zinsmaier, Yan Dong, Yanhua H. Huang in Molecular Psychiatry (2022)

  3. No Access

    Article

    Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal

    Sleep abnormalities are often a prominent contributor to withdrawal symptoms following chronic drug use. Notably, rapid eye movement (REM) sleep regulates emotional memory, and persistent REM sleep impairment ...

    Yao Wang, Rong Guo, Bo Chen, Tanbin Rahman, Li Cai, Yizhi Li… in Molecular Psychiatry (2021)

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    Article

    Chronic sleep fragmentation enhances habenula cholinergic neural activity

    Sleep is essential to emotional health. Sleep disturbance, particularly REM sleep disturbance, profoundly impacts emotion regulation, but the underlying neural mechanisms remain elusive. Here we show that chro...

    Feifei Ge, ** Mu, Rong Guo, Li Cai, Zheng Liu, Yan Dong… in Molecular Psychiatry (2021)

  5. No Access

    Article

    NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward

    The diurnal regulation of dopamine is important for normal physiology and diseases such as addiction. Here we find a novel role for the CLOCK protein to antagonize CREB-mediated transcriptional activity at the...

    Ryan W. Logan, Puja K. Parekh, Gabrielle N. Kaplan… in Molecular Psychiatry (2019)

  6. Article

    Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection

    Exposure to cocaine induces addiction-associated behaviors partially through remodeling neurocircuits in the nucleus accumbens (NAc). The paraventricular nucleus of thalamus (PVT), which projects to the NAc mo...

    Peter A Neumann, Yicun Wang, Yi** Yan, Yao Wang… in Neuropsychopharmacology (2016)

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  7. Article

    Cocaine-Induced Membrane Adaptation in the Central Nucleus of Amygdala

    Exposure to drugs of abuse lead to both rewarding effects and the subsequent development of negative affects. The progressive dysregulation of both processes is thought to critically contribute to the addictiv...

    Bo Chen, Yao-Ying Ma, Yao Wang, **usong Wang, Oliver M Schlüter… in Neuropsychopharmacology (2013)

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