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Article
Open AccessTwo cases of atrial myxoma with calcification and ossification as the main features
Cardiac myxomas are the most common type of primary cardiac tumors in adults, but they can have variable features that make them difficult to diagnose. We report two cases of atrial myxoma with calcification o...
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Article
Open AccessGene activation guided by nascent RNA-bound transcription factors
Technologies for gene activation are valuable tools for the study of gene functions and have a wide range of potential applications in bioengineering and medicine. In contrast to existing methods based on recr...
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Article
Open AccessClinical efficacy of chemotherapy in colorectal cancer patients over 80 years old
Colorectal cancer (CRC) is a common and aggressive gastrointestinal cancer, and the prognostic impact associated with chemotherapy in super elderly (over 80 years old) patients remains poorly defined. We aimed...
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Article
Phase separation of RNA-binding protein promotes polymerase binding and transcription
An RNA-involved phase-separation model has been proposed for transcription control. However, the molecular links that connect RNA to the transcription machinery remain missing. Here we find that RNA-binding pr...
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Article
Open AccessHomotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome
Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation. In an effort to unravel the basic principle underlyi...
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Article
Remarkable response to roxadustat in a case of anti-erythropoietin antibody-mediated pure red cell aplasia
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Article
Correction to: Remarkable response to roxadustat in a case of anti-erythropoietin antibody-mediated pure red cell aplasia
The article “Remarkable response to roxadustat in a case of anti-erythropoietin antibody-mediated pure red cell aplasia”, written by Ke Wan, Yafei Yin, Zimian Luo and Jianzhao Cheng, was originally published o...
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Article
Open AccessAnalytical transient phase change heat transfer model of wearable electronics with a thermal protection substrate
As thermal protection substrates for wearable electronics, functional soft composites made of polymer materials embedded with phase change materials and metal layers demonstrate unique capabilities for the the...
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Article
U1 snRNP regulates chromatin retention of noncoding RNAs
Long noncoding RNAs (lncRNAs) and promoter- or enhancer-associated unstable transcripts locate preferentially to chromatin, where some regulate chromatin structure, transcription and RNA processing1–13. Although ...
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Protocol
Identification of cis-Elements for RNA Subcellular Localization Through REL-seq
The subcellular localization of RNAs is regulated by cis-regulatory elements together with interacting trans factors. Here we describe a high-throughput sequencing-based method named REL-seq (RNA elements for sub...
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Article
Transient thermo-mechanical analysis for bimorph soft robot based on thermally responsive liquid crystal elastomers
Thermally responsive liquid crystal elastomers (LCEs) hold great promise in applications of soft robots and actuators because of the induced size and shape change with temperature. Experiments have successfull...
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Article
Open AccessRNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance
GTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive o...
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Article
Effects of low-dose thalidomide in chronic refractory immune thrombocytopenia and contributions to the dispensation of glucocorticoid dependence
