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  1. Article

    Open Access

    Engineered bacterial outer membrane vesicles encapsulating oncolytic adenoviruses enhance the efficacy of cancer virotherapy by augmenting tumor cell autophagy

    Oncolytic adenovirus (Ad) infection promotes intracellular autophagy in tumors. This could kill cancer cells and contribute to Ads-mediated anticancer immunity. However, the low intratumoral content of intrave...

    Weiyue Ban, Mengchi Sun, Hanwei Huang, Wanxu Huang, Siwei Pan… in Nature Communications (2023)

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  2. Article

    Open Access

    Gene activation guided by nascent RNA-bound transcription factors

    Technologies for gene activation are valuable tools for the study of gene functions and have a wide range of potential applications in bioengineering and medicine. In contrast to existing methods based on recr...

    Ying Liang, Haiyue Xu, Tao Cheng, Yujuan Fu, Hanwei Huang… in Nature Communications (2022)

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  3. Article

    Emerging systemic delivery strategies of oncolytic viruses: A key step toward cancer immunotherapy

    Oncolytic virotherapy (OVT) is a novel type of immunotherapy that induces anti-tumor responses through selective self-replication within cancer cells and oncolytic virus (OV)-mediated immunostimulation. Notabl...

    Weiyue Ban, Jianhuan Guan, Hanwei Huang, Zhonggui He, Mengchi Sun… in Nano Research (2022)

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  4. Article

    Open Access

    Impact of vaccination on the COVID-19 pandemic in U.S. states

    Governments worldwide are implementing mass vaccination programs in an effort to end the novel coronavirus (COVID-19) pandemic. Here, we evaluated the effectiveness of the COVID-19 vaccination program in its e...

    **ao Chen, Hanwei Huang, Jiandong Ju, Ruoyan Sun, Jialiang Zhang in Scientific Reports (2022)

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