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Article
Deciphering Autoimmune Diseases: Unveiling the Diagnostic, Therapeutic, and Prognostic Potential of Immune Repertoire Sequencing
Autoimmune diseases (AIDs) are immune system disorders where the body exhibits an immune response to its own antigens, causing damage to its own tissues and organs. The pathogenesis of AIDs is incompletely und...
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Article
Open AccessBidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i
Metformin and sodium-glucose-cotransporter-2 inhibitors (SGLT2i) are cornerstone therapies for managing hyperglycemia in diabetes. However, their detailed impacts on metabolic processes, particularly within th...
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Article
Open AccessDietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Try...
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Article
Open AccessChild maltreatment exposure and adolescent nonsuicidal self-injury: the mediating roles of difficulty in emotion regulation and depressive symptoms
Although child maltreatment (CM) experiences are recognized risk factors for nonsuicidal self-injury (NSSI), the mechanisms underlying this relationship remain unclear. The purpose of this study was to examine...
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Chapter
Circulating Tumor DNA in Lymphoma
Lymphomas are a heterogeneous group of neoplasms derived from the lymphatic system. They are divided into two categories: Hodgkin lymphoma and non-Hodgkin lymphoma. These tumors have a broad range of molecular...
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Article
Marital status and survival in laryngeal squamous cell carcinoma patients: a multinomial propensity scores matched study
To explore the correlation between the marital status and prognosis of patients with laryngeal squamous cell carcinoma (LSCC).
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Article
Open AccessPrimary small intestine mesenteric low-grade fibromyxoid sarcoma with foci of atypical epithelioid whorls and diffuse DOG1 expression: a case report
Low-grade fibromyxoid sarcoma (LGFMS) is a rare fibroblastic tumor often involving deep tissue of trunk and lower extremities in young to middle-aged patients. Rarely, LGFMS can occur in other sites including ...
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Article
Response of Dendrobium officinale Kimura et Migo, a Prized Medicinal Plant, to Continuous UV-B Irradiation at Different C/N Ratios
The response of Dendrobium officinale Kimura et Migo (D. officinale) to continuous UV-B irradiation at different carbon to nitrogen ratios (C/N ratios) was investigated. Seedlings grown for 60 days were incubated...
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Article
Discrimination of the behavioural dynamics of visually impaired infants via deep learning
Sensory loss is associated with behavioural changes, but how behavioural dynamics change when a sensory modality is impaired remains unclear. Here, by recording under a designed standardized scenario, the beha...
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Article
Effects of soil compaction on plant growth, nutrient absorption, and root respiration in soybean seedlings
Soil compaction is a major environmental problem that affects plant growth and development. In this study, to further our understanding of its negative effects on plant growth, we investigated the effects of s...
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Article
Open AccessA novel approach to determine two optimal cut-points of a continuous predictor with a U-shaped relationship to hazard ratio in survival data: simulation and application
In clinical and epidemiological researches, continuous predictors are often discretized into categorical variables for classification of patients. When the relationship between a continuous predictor and log r...
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Article
The impact of an expressive writing intervention on quality of life among Chinese breast cancer patients undergoing chemotherapy
Expressive writing interventions are shown to confer physical and psychological benefits for Caucasian cancer survivors. This study evaluated the health benefits of an expressive writing intervention among bre...
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Article
Open AccessExtracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis
Serglycin is a proteoglycan that was first found to be secreted by hematopoietic cells. As an extracellular matrix (ECM) component, serglycin promotes nasopharyngeal carcinoma (NPC) metastasis and serves as an...
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Article
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes
The latency of human immunodeficiency virus type 1 (HIV-1) in resting primary CD4+ T cells is the major barrier for the eradication of the virus in patients on suppressive highly active antiretroviral therapy (HA...
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Article
Open AccessUp-regulation of interferon-a/APOBEC3G signal pathway potently inactivates HIV-1 infectivity in resting CD4-T cells
