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Article
Developmental dynamics of RNA translation in the human brain
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the develo** human brain, there is a g...
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Article
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
Although genomic analyses predict many noncanonical open reading frames (ORFs) in the human genome, it is unclear whether they encode biologically active proteins. Here we experimentally interrogated 553 candi...
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Article
Open AccessThe genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation
Unique among cnidarians, jellyfish have remarkable morphological and biochemical innovations that allow them to actively hunt in the water column and were some of the first animals to become free-swimming. The...
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Article
Open AccessThe Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the geneti...
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Article
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
Hair follicle miniaturization is a degenerative process that reduces the dimensions of the epithelial and mesenchymal cell compartments, converting thick hair to fine, downy hair. It is most commonly observed ...
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Article
Open AccessLateral motor column axons execute a ternary trajectory choice between limb and body tissues
Neuronal topographic map formation requires appropriate selection of axonal trajectories at intermediate choice points prior to target innervation. Axons of neurons in the spinal cord lateral motor column (LMC...
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Article
Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase
A transgenic mouse strain with early and uniform expres sion of the Cre site-specific recombinase is described. In this strain, PGK-Crem, Cre is driven by the early acting PGK-1 promoter, but, probably due to ...
