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Article
Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors
Members of the fibroblast growth factor (FGF) family play diverse roles during the development and patterning of various organs. In human and mice, 22 FGFs and four receptors derived from several splice varian...
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Article
Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation
The role of FGF signaling in early epithelial differentiation was investigated in ES (embryonic stem) cell derived embryoid bodies. A dominant negative fibroblast growth factor receptor (FGFR) mutation was cre...
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Article
Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase
A transgenic mouse strain with early and uniform expres sion of the Cre site-specific recombinase is described. In this strain, PGK-Crem, Cre is driven by the early acting PGK-1 promoter, but, probably due to ...
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Article
Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation
Two receptor tyrosine kinases, ErB-3 and ErbB-4, mediate signaling by Neu differentiation factors (NDFs, also called neuregulins), while ErbB-1 and ErbB-2 serve as co-receptors. We show that the two NDF/neureg...
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Chapter
Somatic T Cell Hybrids in the Analysis of H-2 Restriction and Antigen Recognition
In this synopsis I will discuss a few recent experiments from our laboratory, which studied helper factors of T cell hybridomas. I will also analyze certain old and new approaches, which hitherto were little u...
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Article
Role of the major histocompatibility complex in resistance to viral leukemia; Its effect on the preleukemic stage of leukemogenesis
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Article
H-2I-linked control of immunological resistance to viral leukemogenesis as a response to preleukemic cells
The mechanism of resistance to leukemogenesis by two radiation leukemia virus variants, A-RadLV and D-RadLV, was investigated. Resistance to these viruses is linked toH-2I in both B10.S and C57BL/10 mice. The res...
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Article
Genetic resistance to murine leukemia induced by different radiation leukemia virus variants; a comparative study on the role of theH-2 complex
Association of resistance to leukemogenesis with theH-2 complex was investigated. Three variants of the radiation leukemia virus: D-RadLV, RadLV and RS-RadLV were tested. Using congenic and recombinant mouse stra...
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Article
I-region linked complementing loci in resistance to viral leukemogenesis in the mouse
A-RadLV, a variant of the radiation leukemia virus, inoculated intrathymically into adult mice, causes a high frequency of leukemia in haplotypesb, f, k, d, p andj on the B10 background, whereas H-2S mice are res...
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Article
Selective expression of murine lymphocyte alloantigens controlled by the X-chromosome
Alloantisera specific to X-chromosome linked lymphocyte membrane antigens (Ly-X) were prepared by immunizing F1 male mice with identical F1 female lymphocytes. Independent B cell specific (anti Lyb-X) and T ce...
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Article
The expression ofI-region gene products on lymphocytes
MLR reactivity of lymphocytes from a large number of strain combinations, devised to differ for restricted regions of theH-2 complex, was studied. The reactivities of T and B stimulator cells were compared. It wa...
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Article
The expression of I-region gene products on lymphocytes
Mixed lymphocyte reaction (MLR) stimulation by purified T and B lymphocytes and thymocytes was studied. The MLR gene products involved were localized to theH-2 complex by the use of congenic mice differing atH-2,...
