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Article
Open AccessMulti-centric evaluation of Truenat MTB and MTB-RIF Dx assays for diagnosis of extrapulmonary tuberculosis
Extra-pulmonary TB (EPTB) is difficult to diagnose due to paucibacillary nature of disease. Current study evaluated accuracy of Truenat MTB and MTB-Rif Dx (TN), for detection of Mycobacterium tuberculosis and res...
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Presumed ocular tuberculosis – need for caution before considering anti-tubercular therapy
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Article
GeneXpert Ultra in Urine Samples for Diagnosis of Extra-Pulmonary Tuberculosis
Extra-pulmonary tuberculosis (EPTB) continues to be difficult to diagnose. Novel biomarkers in biological specimens offer promise. Detection of Mycobacterium tuberculosis (Mtb) DNA in urine could prove useful in ...
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Article
Open AccessExpedited diagnosis of pediatric tuberculosis using Truenat MTB-Rif Dx and GeneXpert MTB/RIF
Rapid, cost-effective, and sensitive diagnostic assays are essential for global tuberculosis (TB) control, especially in high TB burden, resource-limited settings. The current study was designed to evaluate di...
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Article
Open AccessCorrection to: Efficacy of Bacillus Calmette–Guérin (BCG) Vaccination in Reducing the Incidence and Severity of COVID-19 in High-Risk Population (BRIC): a Phase III, Multi-centre, Quadruple-Blind Randomised Control Trial
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Article
Open AccessEfficacy of Bacillus Calmette–Guérin (BCG) Vaccination in Reducing the Incidence and Severity of COVID-19 in High-Risk Population (BRIC): a Phase III, Multi-centre, Quadruple-Blind Randomised Control Trial
Universal coverage of vaccines alone cannot be relied upon to protect at-risk populations in lower- and middle-income countries against the impact of the coronavirus disease 2019 (COVID-19) pandemic and newer ...
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Article
Early pharmacokinetic evaluation of anti-tubercular treatment as a good indicator of treatment success in pulmonary tuberculosis patients on a retreatment regimen
Patients with pulmonary tuberculosis (PTB) who fail therapy or develop a relapse are initiated on a retreatment regimen. These patients are at high risk for adverse outcomes. This study aimed to assess the rel...
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Repurposing of Carbapenems for the Treatment of Drug-Resistant Tuberculosis
The World Health Organization (WHO) estimated that there were 1.6 million deaths worldwide in 2017 from tuberculosis (TB). Today, TB kills more humans than any other infectious agent, even surpassing HIV/AIDS ...
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Article
Diagnostic Yield of Xpert MTB/RIF in Bronchoalveolar Lavage in Children with Probable Pulmonary Tuberculosis
To evaluate utility of Xpert MTB/RIF in bronchoalveolar lavage fluid in children with probable pulmonary tuberculosis.
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Article
Predictors of Microbiologically Confirmed Intrathoracic Tuberculosis
To identify risk factors for microbiologically confirmed intrathoracic tuberculosis in children.
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Article
Open AccessPrevalence of pulmonary tuberculosis in young adult patients with Type 1 diabetes mellitus in India
There is limited information on prevalence of pulmonary tuberculosis (PTB) in patients with type-1-diabetes. We assessed the prevalence of PTB in patients with type-1-diabetes attending the outpatient-clinic i...
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Article
In the search of a cause of Crohn’s disease
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Open AccessMycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligoty** database (SpolDB4) for classification, population genetics and epidemiology
The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligoty** is the widely used PCR...
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Article
Spectrum of Pulmonary Infections in Renal Transplant Recipients in the Tropics: A Single Center Study
Background: Pulmonary infections have been implicated as the most common cause of infection related mortality in renal transplant recipients. An appropriate empirical treatment of post tr...
