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Diagnostic Yield of Xpert MTB/RIF in Bronchoalveolar Lavage in Children with Probable Pulmonary Tuberculosis

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Abstract

Objective

To evaluate utility of Xpert MTB/RIF in bronchoalveolar lavage fluid in children with probable pulmonary tuberculosis.

Methods

Children with probable pulmonary tuberculosis with negative smear and Xpert on induced sputum/gastric aspirate were subjected to bronchoalveolar lavage (BAL) for Xpert assay and mycobacterial liquid culture. Data of children <14 y undergoing bronchoscopy for suspected MDR-TB (n=12) were also analyzed. The sensitivity of Xpert in BAL fluid for diagnosis of probable and confirmed pulmonary tuberculosis was calculated with clinico-radiological diagnosis and culture as gold standards, respectively.

Results

Of 41 enrolled children, 24 (58.5%) had Xpert positive in BAL fluid and 11 (26.8%) had culture confirmed tuberculosis (BAL fluid;10; sputum,1). The sensitivity of Xpert in BAL fluid among probable and culture confirmed tuberculosis cases was 58.5% (24/41) and 81.8% (9/11), respectively.

Conclusion

Xpert in bronchoalveolar lavage fluid has good sensitivity in both probable and confirmed pulmonary tuberculosis in children.

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Authors and Affiliations

  1. Departments of Pediatrics, All India Institute of Medical Sciences, New Delhi, India

    Isha Saini, Aparna Mukherjee, Mohit Singla, Kr Jat, Rakesh Lodha & Sk Kabra

  2. Departments of Microbiology, All India Institute of Medical Sciences, New Delhi, India

    Hitender Gautam & Urvashi B Singh

Authors
  1. Isha Saini
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  2. Aparna Mukherjee
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  3. Hitender Gautam
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  4. Mohit Singla
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  5. Kr Jat
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  6. Rakesh Lodha
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  7. Urvashi B Singh
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  8. Sk Kabra
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Correspondence to Sk Kabra.

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Saini, I., Mukherjee, A., Gautam, H. et al. Diagnostic Yield of Xpert MTB/RIF in Bronchoalveolar Lavage in Children with Probable Pulmonary Tuberculosis. Indian Pediatr 55, 1062–1065 (2018). https://doi.org/10.1007/s13312-018-1443-9

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  • DOI: https://doi.org/10.1007/s13312-018-1443-9

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