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Article
MiR-326-mediated overexpression of NFIB offsets TGF-β induced epithelial to mesenchymal transition and reverses lung fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a progressively fatal and incurable disease characterized by the loss of alveolar structures, increased epithelial–mesenchymal transition (EMT), and aberrant tissue repai...
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Article
Persistence of SARS-CoV-2 Antibodies for a Year Following SARS-CoV-2 Vaccinations (BBV152 and ChAdOx1 nCoV-19)
The first two vaccines administered in the COVID-19 vaccination campaign of India were Covaxin (BBV152) and Covishield (ChAdOx1-nCoV-19). In this study, we evaluate the longevity and sustainability of the humo...
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Article
Open AccessTest concordance and diagnostic accuracy of three serological assays for detection of anti-SARS-CoV-2 antibody: result from a population-based sero-epidemiological study in Delhi
Several methodological tests are available to detect SARS-CoV-2 antibody. Tests are mostly used in the aid of diagnosis or for serological assessment. No tests are fully confirmatory and have variable level of...
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Article
Respiratory Deposition Dose of PM2.5 and PM10 Before, During and After COVID-19 Lockdown Phases in Megacity-Delhi, India
Considerable changes in particulate matter (PM) during COVID-19 lockdown in major cities around the World demand changes in exposure assessment studies of PM. The present study shows variations in respiratory ...
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Article
Open AccessStatin and aspirin as adjuvant therapy in hospitalised patients with SARS-CoV-2 infection: a randomised clinical trial (RESIST trial)
Statins and aspirin have been proposed for treatment of COVID-19 because of their anti-inflammatory and anti-thrombotic properties. Several observational studies have shown favourable results. There is a need ...
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Article
Early pharmacokinetic evaluation of anti-tubercular treatment as a good indicator of treatment success in pulmonary tuberculosis patients on a retreatment regimen
Patients with pulmonary tuberculosis (PTB) who fail therapy or develop a relapse are initiated on a retreatment regimen. These patients are at high risk for adverse outcomes. This study aimed to assess the rel...
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Article
Comparison of 68Ga-DOTANOC PET/CT with cardiac MRI in patients with clinical suspicion of cardiac sarcoidosis
68Ga-DOTA-NaI-octreotide (DOTANOC) is a promising new alternative to 18F-fluorodeoxyglucose (FDG) for imaging inflammation in cardiac sarcoidosis. The aim of the study was to compare 68Ga-DOTANOC positron emissio...
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Article
Effects of ambient air pollution on emergency room visits of children for acute respiratory symptoms in Delhi, India
The present study explored the association between daily ambient air pollution and daily emergency room (ER) visits due to acute respiratory symptoms in children of Delhi. The daily counts of ER visits (ERV) o...
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Article
Artificial Intelligence–assisted chest X-ray assessment scheme for COVID-19
To study whether a trained convolutional neural network (CNN) can be of assistance to radiologists in differentiating Coronavirus disease (COVID)–positive from COVID-negative patients using chest X-ray (CXR) t...
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Article
Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians
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Article
Open AccessAtorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial
To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients infected with SARS-CoV-2 who require hospitalisation. The safety of these drugs in COVID-19 patients wi...
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Article
Differential expression of circulating serum miR-1249-3p, miR-3195, and miR-3692-3p in non-small cell lung cancer
Global deregulation in miRNA expression is a hallmark of cancer cell. An estimated 2300 mature miRNAs are encoded by human genome; role of many of which in carcinogenesis and as cancer biomarkers remains unexp...
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Acute Respiratory Failure
A 30-year-old male patient presented with acute onset of breathlessness, dry cough, fever, myalgia, and malaise for 4 days. On examination, he was found to be febrile and restless, with respiratory rate of 46/...
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Article
Open AccessThe time required to diagnose and treat lung cancer in Delhi, India: an updated experience of a public referral center
Delays that postpone the evaluation and management of malignancy may lead to considerable morbidity. The primary objective of this study was to assess the time required to diagnose and treat lung cancer at an ...
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Article
Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians
Obstructive sleep apnea (OSA) has been estimated to affect 4–11% of the population and causes systemic inflammation which leads to metabolic syndrome (MS). Non-alcoholic fatty liver disease (NAFLD) is also ass...
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Article
Open AccessGenetic polymorphisms associated with treatment failure and mortality in pediatric Pneumocystosis
Data on the genetic diversity of Pneumocystis jirovecii causing Pneumocystis pneumonia (PCP) among children are still limited, and there are no available data from the Indian subcontinent, particularly associatio...
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Chapter
Health Effects of Changing Environment
Environment plays a crucial role in our economic, social and cultural behaviour as well as on health. However, since the beginning of industrialization era, focus on economic development has caused detrimental...
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Article
Open AccessTrends of loss of peripheral muscle thickness on ultrasonography and its relationship with outcomes among patients with sepsis
Data regarding trends of muscle loss on ultrasonography (USG) and its relationship with various outcomes among critically ill patients is limited. This study aimed to describe the trends of loss of muscle thic...
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Article
Open AccessPrevalence of pulmonary tuberculosis in young adult patients with Type 1 diabetes mellitus in India
There is limited information on prevalence of pulmonary tuberculosis (PTB) in patients with type-1-diabetes. We assessed the prevalence of PTB in patients with type-1-diabetes attending the outpatient-clinic i...
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Article
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) in Mediastinal Lymphadenopathy
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) is accepted as a safe and minimally invasive modality for evaluation of mediastinal pathologies in adults. There is scanty literatur...
