-
Article
Open AccessDiagnosis and treatment status of inoperable locally advanced breast cancer and the application value of inorganic nanomaterials
Locally advanced breast cancer (LABC) is a heterogeneous group of breast cancer that accounts for 10–30% of breast cancer cases. Despite the ongoing development of current treatment methods, LABC remains a sev...
-
Article
Strand displacement–triggered FRET nanoprobe tracking TK1 mRNA in living cells for ratiometric fluorimetry of nucleic acid biomarker
A precisely designed dual-color biosensor has realized a visual assessment of thymidine kinase 1 (TK1) mRNA in both living cells and cell lysates. The oligonucleotide probe is constructed by hybridizing the an...
-
Article
Pre-hepatectomy dynamic circulating tumor DNA to predict pathologic response to preoperative chemotherapy and post-hepatectomy recurrence in patients with colorectal liver metastases
To evaluate the predictive value of pre-hepatectomy dynamic circulating tumor DNA (ctDNA) on pathologic response to preoperative chemotherapy and recurrence after liver resection for colorectal liver metastase...
-
Article
Open AccessP4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway
Head and neck squamous cell carcinoma (HNSCC) can be defined as a deadly illness with a dismal prognosis in advanced stages. Therefore, we seek to examine P4HA2 expression and effect in HNSCC, along with the u...
-
Article
Open AccessClinical significance of pleural fluid lactate dehydrogenase/adenosine deaminase ratio in the diagnosis of tuberculous pleural effusion
Pleural fluid is one of the common complications of thoracic diseases, and tuberculous pleural effusion (TPE) is the most common cause of pleural effusion in TB-endemic areas and the most common type of exudat...
-
Article
Open AccessUnveiling rootstock-induced dwarfing from comparative genomic analysis
-
Article
Preparation and properties of porous silicon anode coated with nitrogen-doped carbon for lithium-ion battery
Silicon (Si) is a promising anode material for next-generation lithium-ion batteries (LIBs) with its high theoretical specific capacity (4200 mAh/g). However, Si anode has a huge volume change rate (> 300%) an...
-
Article
Open AccessGlobal annual wetland dataset at 30 m with a fine classification system from 2000 to 2022
Wetlands play a key role in maintaining ecological balance and climate regulation. However, due to the complex and variable spectral characteristics of wetlands, there are no publicly available global 30-meter...
-
Article
Open AccessTMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9
Breast cancer stem cell (CSC) expansion results in tumor progression and chemoresistance; however, the modulation of CSC pluripotency remains unexplored. Transmembrane protein 120B (TMEM120B) is a newly discov...
-
Article
Comparison of Protective Effect of Tri-circulator and Coenzyme Q10 on Myocardial Injury and the Mechanism Study by Zebrafish Model
Tri-Circulator (TC) is a product comprising coenzyme Q10 (CoQ10), Salvia miltiorrhiza, and Panax notoginseng. Individually, each of these constituents has demonstrated protective effects on myocardial injury. The...
-
Article
Can99mTc-MDP–SPECT/CT Differentiate Loosening and Infection After Hip and Knee Replacements?
Prosthetic loosening and infection are still common complications after joint replacement. Over the past few years, single-photon emission computed tomography–computed tomography (SPECT/CT) was widely used and...
-
Article
Open AccessClinical and genetic characterization of 47 Chinese pediatric patients with Pitt–Hopkins syndrome: a retrospective study
Pitt–Hopkins syndrome (PTHS) is a neurodevelopmental disorder that remains underdiagnosed and its clinical presentations and mutation profiles in a diverse population are yet to be evaluated. This retrospectiv...
-
Article
Open AccessBlockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner
Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and developmen...
-
Article
pparβ regulates lipid catabolism by mediating acox and cpt-1 genes in Scophthalmus maximus under heat stress
Peroxisome proliferator–activated receptor β (pparβ) is a key gene–regulating lipid metabolism pathway, but its function in turbot remains unclear. In this study, the CDS of pparβ was cloned from kidney for the f...
-
Article
Open AccessModified Gexia-Zhuyu Tang inhibits gastric cancer progression by restoring gut microbiota and regulating pyroptosis
Gexia-Zhuyu Tang (GZT), a traditional Chinese medicine formula, is used to treat a variety of diseases. However, its roles in gastric cancer (GC) remain unclear.
-
Article
The Untargeted Metabolomics Reveals Differences in Energy Metabolism in Patients with Different Subtypes of Ischemic Stroke
Ischemic stroke (IS) is the most common subtype of stroke. The risk factors and pathogenesis of IS are complex and varied due to different subtypes. Therefore, we used metabolomics technology to investigate th...
-
Article
Open AccessA skin-conformal and breathable humidity sensor for emotional mode recognition and non-contact human-machine interface
Noncontact humidity sensor overcomes the limitations of its contact sensing counterparts, including mechanical wear and cross infection, which becomes a promising candidate in healthcare and human-machine inte...
-
Article
Open AccessPotato calcium sensor modules StCBL3-StCIPK7 and StCBL3-StCIPK24 negatively regulate plant immunity
Potato late blight, caused by Phytophthora infestans, is the most devastating disease on potato. Dissecting critical immune components in potato will be supportive for engineering P. infestans resistance. Upon pa...
-
Article
Open AccessSTAT3 and SOX-5 induce BRG1-mediated chromatin remodeling of RORCE2 in Th17 cells
Retinoid-related orphan receptor gamma t (RORγt) is the lineage-specific transcription factor for T helper 17 (Th17) cells. Our previous study demonstrated that STAT3 likely participates in the activation of R...
-
Article
Open AccessAutomating General Movements Assessment with quantitative deep learning to facilitate early screening of cerebral palsy
The Prechtl General Movements Assessment (GMA) is increasingly recognized for its role in evaluating the integrity of the develo** nervous system and predicting motor dysfunctions, particularly in conditions...
