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  1. Article

    Open Access

    Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction

    Despite the high prevalence of ischemic heart diseases worldwide, no antibody-based treatment currently exists. Starting from the evidence that a specific isoform of the Bone Morphogenetic Protein 1 (BMP1.3) i...

    Slobodan Vukicevic, Andrea Colliva, Vera Kufner… in Nature Communications (2022)

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  2. Article

    Open Access

    A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis

    Bone morphogenetic proteins (BMPs) are involved in the development and homeostasis of multiple organs and tissues. There has been a significant focus on understanding the role of BMPs in pancreatic β-cell dysf...

    Martina Pauk, Tatjana Bordukalo-Niksic, Jelena Brkljacic… in Acta Diabetologica (2019)

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    Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction

    Complications associated with the clinical use of BMP2 and BMP7 result from the limited understanding of their molecular mechanisms in bone remodeling. Recently, a novel BMP6-based approach has been developed ...

    Lovorka Grgurevic, Igor Erjavec… in Bone Morphogenetic Proteins: Systems Biolo… (2017)

  4. No Access

    Article

    Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice

    Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene. We investigated involvement of other BMP...

    Martina Pauk, Lovorka Grgurevic, Jelena Brkljacic… in International Orthopaedics (2015)

  5. No Access

    Article

    Systemically available bone morphogenetic protein two and seven affect bone metabolism

    Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone admini...

    Ivo Dumic-Cule, Jelena Brkljacic, Dunja Rogic… in International Orthopaedics (2014)

  6. No Access

    Article

    The clinical use of bone morphogenetic proteins revisited: a novel biocompatible carrier device OSTEOGROW for bone healing

    The purpose of this study was to revise the clinical use of commercial BMP2 (Infuse) and BMP7 (Osigraft) based bone devices and explore the mechanism of action and efficacy of low BMP6 doses in a novel whole b...

    Slobodan Vukicevic, Hermann Oppermann, Donatella Verbanac… in International Orthopaedics (2014)

  7. No Access

    Article

    Neuronal tryptophan hydroxylase (TPH2) in suicidal behaviour

    Serotonin (5-hydroxytryptamine, 5-HT) is a signalling molecule involved in many brain functions as well as in a variety of psychiatric conditions, including suicidal behaviour. Tryptophan hydroxylase (TPH), th...

    Jasminka Štefulj, Tatjana Bordukalo-Nikšić in Translational Neuroscience (2010)

  8. No Access

    Article

    Hyperserotonemia in autism: activity of 5HT-associated platelet proteins

    Disturbances in serotonin (5HT) neurotransmission have been indicated as biological substrates in several neuropsychiatric disorders including autism. Blood 5HT concentrations, elevated in about one-third of a...

    Dubravka Hranilović, Zorana Bujas-Petković, Maja Tomičić… in Journal of Neural Transmission (2009)