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Article
Open AccessThe effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional c...
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Chapter
Mild Plant and Dietary Immunomodulators
Plants and minerals have been used since ancient times for the treatment of many ailments and diseases. Most were used for mystical reasons and others relied on the “doctrine of signatures”, which stated that ...
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Article
Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides
Novel nitro (3a–3f)- and amino (4a–4f and 5a–5f)-substituted 2-benzimidazolyl and 2-benzothiazolyl benzo[b]thieno-2-carboxamides were designed and synthesized as potential antibacterial agents. The antibacterial ...
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Article
Open AccessMethodology challenges in studying human gut microbiota – effects of collection, storage, DNA extraction and next generation sequencing technologies
The information on microbiota composition in the human gastrointestinal tract predominantly originates from the analyses of human faeces by application of next generation sequencing (NGS). However, the detecte...
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Article
The clinical use of bone morphogenetic proteins revisited: a novel biocompatible carrier device OSTEOGROW for bone healing
The purpose of this study was to revise the clinical use of commercial BMP2 (Infuse) and BMP7 (Osigraft) based bone devices and explore the mechanism of action and efficacy of low BMP6 doses in a novel whole b...
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Article
6-Imino-2-thioxo-pyrimidinones as a new class of dipeptidyl peptidase IV inhibitors
Dipeptidyl peptidase IV is a glycoprotein which removes N-terminal dipeptides from physiologically relevant polypeptides. An homologous series of 6-imino-2-thioxo-5-{[3,4,5-tris(methyloxy)phenyl]methyl}-2,5-di...
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Chapter
C9 Mild plant and dietary immunomodulators
Plants and minerals have been used since ancient times for the treatment of many ailments and diseases. Most were used for mystical reasons and others relied on the “doctrine of signatures”, which stated that ...
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Chapter
Mild plant and dietary immunomodulators
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Article
Tissue zinc dynamics during the immune reaction in mice
Owing to the importance of zinc for the functioning of the immune system, the role of endogenous Zn, located both in lymphoid and nonlymphoid organs, was investigated during the standard humoral and cellular t...
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Article
Determination of standard zinc values in the intact tissues of mice by ICP spectrometry
The most commonly encountered difficulties for the quantitative measurement of zinc in biological samples are the limited sample amount, total and effective digestion of connective and fatty residues, and low ...
