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Article
Open AccessUtility of the refined EBMT diagnostic and severity criteria 2023 for sinusoidal obstruction syndrome/veno-occlusive disease
Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT). Early diagnosis of SOS/VOD is associated with improved cli...
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Article
Open AccessDevelopment and nationwide validation of kidney graft injury markers using urinary exosomes and microvesicles (complete English translation of the Japanese version)
Non-invasive, prompt, and proper detection tools for kidney graft injuries (KGIs) are awaited to ensure graft longevity. We screened diagnostic biomarkers for KGIs following kidney transplantation using extrac...
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Article
Primary cutaneous Langerhans cell sarcoma without evident Birbeck granules: the importance of CD207/langerin positivity
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Article
Open AccessAuthor Correction: Survival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small-cell lung cancer
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Article
Open AccessAdaptive resistance to lorlatinib via EGFR signaling in ALK-rearranged lung cancer
Anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors rarely elicit complete responses in patients with advanced ALK-rearranged non-small cell lung cancer (NSCLC), as a small population of tumor cells su...
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Article
A Case of Recurrent Ovarian Cancer with Renal Dysfunction Associated with the Use of Olaparib
Olaparib (ORB) is known not to largely affect renal function due to its specific pharmacological mechanism, and there are no reports on renal dysfunction associated with the drug. The patient was found to have...
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Article
Open AccessDiagnostic error rates and associated factors for lower gastrointestinal perforation
Lower gastrointestinal perforation is rare and challenging to diagnose in patients presenting with an acute abdomen. However, no study has examined the frequency and associated factors of diagnostic errors rel...
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Article
Open AccessSurvival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small-cell lung cancer
Chronic obstructive pulmonary disease (COPD) may coexist with lung cancer, but the impact on prognosis is uncertain. Moreover, it is unclear whether pharmacological treatment for COPD improves the patient’s pr...
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Article
Open AccessMCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression
There have been few advances in the treatment of small-cell lung cancer (SCLC) because of the lack of targets. MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, i...
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Article
Open AccessYAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
Despite the promising clinical efficacy of the second-generation anaplastic lymphoma kinase (ALK) inhibitor alectinib in patients with ALK-rearranged lung cancer, some tumor cells survive and eventually relaps...
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Article
Open AccessClinical impact of low serum free T4 in patients with non-small cell lung cancer treated with nivolumab
Nivolumab improves the prognosis of non-small cell lung cancer (NSCLC) but can cause immune-related adverse events (irAEs). Reports have indicated longer progression-free survivals (PFSs) in patients with irAE...
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Article
Open AccessClinicopathological characteristics of thrombospondin type 1 domain-containing 7A-associated membranous nephropathy
Thrombospondin type 1 domain-containing 7A (THSD7A) is a recently identified target antigen of idiopathic membranous nephropathy (iMN). The clinicopathological characteristics of THSD7A-associated MN are poorl...
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Article
Life-threatening bleeding episodes in primary immune thrombocytopenia: a single-center retrospective study of 169 inpatients
Bleeding is the most important clinical outcome in patients with immune thrombocytopenia (ITP), and the goal of therapy in such cases is to treat or prevent bleeding. The frequency of and risk factors for blee...
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Article
Open AccessAn immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator
Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in ...
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Article
Open AccessClinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients
This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with ni...
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Article
Crystal-storing histiocytosis complicating marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
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Article
Open Accessc-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates
Appropriate parental care by fathers greatly facilitates health in human family life. Much less is known from animal studies regarding the factors and neural circuitry that affect paternal behavior compared wi...
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Article
Open AccessA high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome
Lymphoma-associated hemophagocytic syndrome (LAHS), which is the major subtype of adult-onset secondary hemophagocytic lymphohistiocytosis (HLH), has a poor outcome. Although the early diagnosis and treatment ...
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Article
Open AccessDisplays of paternal mouse pup retrieval following communicative interaction with maternal mates
Compared with the knowledge of maternal care, much less is known about the factors required for paternal parental care. Here we report that new sires of laboratory mice, though not spontaneously parental, can ...
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Article
Therapy with lenalidomide plus dexamethasone-induced bone formation in a patient with refractory multiple myeloma
Bone disease is a major symptom of multiple myeloma, which results from excessive osteoclast activation and impaired osteoblast function. Novel antimyeloma agents, such as immunomodulatory drugs and bortezomib...
