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Article
Open AccessIsobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody
The low response rate of immune checkpoint inhibitors (ICIs) is a challenge. The efficacy of ICIs is influenced by the tumour microenvironment, which is controlled by the gut microbiota. In particular, intesti...
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Article
Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial
This study evaluated the efficacy of Valeriana officinalis L. and Passiflora incarnata L. to control anxiety, surgical discomfort, and changes in vital signs of patients undergoing extraction of two unilateral...
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Article
Open AccessIncidence of coronary heart disease among remote workers: a nationwide web-based cohort study
Coronary heart disease (CHD) risk is influenced by socioeconomic status-related parameters, particularly occupation. We investigated occupational gaps in CHD risk and how the introduction of remote work modera...
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Article
Open AccessButyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer
Recently, intestinal bacteria have attracted attention as factors affecting the prognosis of patients with cancer. However, the intestinal microbiome is composed of several hundred types of bacteria, necessita...
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Article
Open AccessMeasurement of Bisphenol A Diglycidyl Ether (BADGE), BADGE derivatives, and Bisphenol F Diglycidyl Ether (BFDGE) in Japanese infants with NICU hospitalization history
Bisphenol A diglycidyl ether (BADGE) and Bisphenol F diglycidyl ether (BFDGE) are used in medical devices, such as intravenous sets, syringes, and catheters. Several studies have reported that these compounds ...
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Article
Open AccessExtracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane
α-Synuclein (αS), the causative protein of Parkinson’s disease and other α-synucleinopathies, aggregates from a low molecular weight form (LMW-αS) to a high molecular weight αS oligomer (HMW-αSo). Aggregated α...
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Article
Open AccessSleep quality and temperament in association with autism spectrum disorder among infants in Japan
Sleep problems and irritable temperaments are common among infants with autism spectrum disorder (ASD). The prospective association between such sleep problems and irritable temperaments and ASDs needs to be d...
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Article
Open AccessEffect of COVID-19 infection related experiences on social behaviors when a state of emergency is declared: a cohort study
Restricting the movement of the public to gathering places and limiting close physical contact are effective measures against COVID-19 infection. In Japan, states of emergency have been declared in specific pr...
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Article
Open AccessA CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure
Valproic acid (VPA) is a clinically used antiepileptic drug, but it is associated with a significant risk of a low verbal intelligence quotient (IQ) score, attention-deficit hyperactivity disorder and autism s...
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Article
Open AccessAssociation of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants
We hypothesized that maternal lifestyle factors, such as physical activity and sleep habits, may be associated with autism spectrum disorder (ASD) in infants. This study aimed to investigate the association be...
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Article
Open AccessLack of catch-up in weight gain may intermediate between pregnancies with hyperemesis gravidarum and reduced fetal growth: the Japan Environment and Children’s Study
Women with nausea and vomiting of pregnancy (NVP) have higher birth weight infants, while those with hyperemesis gravidarum, a severe manifestation of NVP, have lower birth weight infants. We aimed to investig...
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Article
Open AccessEffect of commuting on the risk of COVID-19 and COVID-19-induced anxiety in Japan, December 2020
To prevent the spread of coronavirus disease (COVID-19), it is important to avoid 3Cs (closed spaces, crowded places, and close-contact settings). However, the risk of contact with an unspecified number of peo...
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Article
Open AccessIndustry and workplace characteristics associated with the downloading of a COVID-19 contact tracing app in Japan: a nation-wide cross-sectional study
To combat coronavirus disease 2019 (COVID-19), many countries have used contact tracing apps, including Japan’s voluntary-use contact-confirming application (COCOA). The current study aimed to identify industr...
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Article
Open AccessMaternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), are three reportedly predictive biomarkers that reflect subclinical chronic inflammatory burden....
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Article
Open AccessAssociation of maternal sleep before and during pregnancy with sleep and developmental problems in 1-year-old infants
This study investigated the association of maternal sleep before and during pregnancy with slee** and developmental problems in 1-year-old infants. We used data from the Japan Environment and Children’s Stud...
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Article
Open AccessInfluence of physical activity before and during pregnancy on infant’s sleep and neurodevelopment at 1-year-old
The aim of this study was to investigate the association between maternal physical activity (PA) before and during pregnancy and sleep and developmental problems in 1-year-old infants. We used data from a nati...
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Article
Open AccessSubstitution of Thr572 to Ala in mouse c-Myb attenuates progression of early erythroid differentiation
The expression level of transcription factor c-Myb oscillates during hematopoiesis. Fbw7 promotes ubiquitin-mediated degradation of c-Myb, which is dependent on phosphorylation of Thr572. To investigate the ph...
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Article
Open AccessNon-reassuring foetal status and sleep problems in 1-year-old infants in the Japan Environment and Children’s Study: a cohort study
Abnormal autonomic function may cause false-positive non-reassuring foetal status (fpNRFS) and may also cause slee** problems after birth. However, an association between fpNRFS and slee** problems in infants...
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Article
Open AccessAssociation of maternal sleep before and during pregnancy with preterm birth and early infant sleep and temperament
This study aimed to investigate the association of maternal sleep before and during pregnancy with preterm birth, infant sleep and temperament at 1 month of age. We used the data of the Japan Environment and C...
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Article
Open AccessImpact of sleep duration during pregnancy on the risk of gestational diabetes in the Japan environmental and Children’s study (JECS)
Gestational diabetes mellitus (GDM) has serious effects on both mother and child. Like Type 2 Diabetes Mellitus, it is increasing in prevalence world-wide. In addition to obesity, sleep duration has been named...
