111 Result(s)

Article

Fulminante Infektion und serologisch nichtbestimmbare Blutgruppe

Morbus Bruton („X-linked agammaglobulinaemia“, XLA) ist ein primärer Immundefekt aufgrund von Mutationen im BTK-Gen. Es liegt eine Differenzierungsstörung der B‑Zellen mit fehlender oder aberranter Immunglobulinp...

S. Fritzemeyer, R. Kosteczka, A. Lieb, R. Schrewe… in Monatsschrift Kinderheilkunde (2020)

Article

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

The pharmacokinetics (PK) of the 20S proteasome inhibitor bortezomib are characterized by a large volume of distribution and a rapid decline in plasma concentrations within the first hour after administration....

Julie M. Janssen, T. P. C. Dorlo, D. Niewerth, A. J. Wilhelm… in Clinical Pharmacokinetics (2020)

Article

Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group

Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Mar...

A Balduzzi, J-H Dalle, K Jahnukainen, M von Wolff… in Bone Marrow Transplantation (2017)

Article

State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29–30 September 2015

Nowadays, allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment procedure and often the only cure for many patients with malignant and non-malignant diseases. Decrease...

J-H Dalle, G Lucchini, A Balduzzi, M Ifversen, K Jahnukainen… in Bone Marrow Transplantation (2017)

Article

Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival

U Creutzig, M N Dworzak, M Zimmermann, J-P Bourquin, B Gruhn, G Fleischhack… in Leukemia (2015)

Article

Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment

The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is poor. Here, we assessed the prognostic importance of response during induction and consolidation treatment prior to hema...

C Eckert, N Hagedorn, L Sramkova, G Mann, R Panzer-Grümayer, C Peters… in Leukemia (2015)

Article

Dendritic cell reconstitution is associated with relapse-free survival and acute GVHD severity in children after allogeneic stem cell transplantation

DCs are potent APCs and key regulators of innate and adaptive immunity. After allo-SCT, their reconstitution in the peripheral blood (PB) to levels similar to those in healthy individuals tends to be slow. We ...

M C Elze, O Ciocarlie, A Heinze, S Kloess, T Gardlowski… in Bone Marrow Transplantation (2015)

Article

High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from the European Rhabdoid Registry (EU-RHAB)

A retrospective analysis of data from the European Rhabdoid Registry (EU-RHAB) was performed to describe the outcome of children with atypical teratoid/rhabdoid tumors (AT/RT) who underwent high-dose chemother...

M Benesch, K Bartelheim, G Fleischhack, B Gruhn… in Bone Marrow Transplantation (2014)

Chapter

Weichteilsarkome

Weichteilsarkome (WTS) stellen eine sehr heterogene Gruppe maligner Tumoren dar. Sie entstehen primär in den Weichteilen, sind mesenchymaler Herkunft und bilden die viertgrößte Gruppe solider Tumoren im Kindes...

T. Klingebiel, E. Koscielniak in Uroonkologie (2014)

Article

Feasibility of IL-15-activated cytokine-induced killer cell infusions after haploidentical stem cell transplantation

E Rettinger, H Bonig, S Wehner, G Lucchini, A Willasch… in Bone Marrow Transplantation (2013)

Article

Allo-SCT using BU, CY and melphalan for children with AML in second CR

Based on the results from the AML-BFM 98 trial, hematopoietic SCT (HSCT) is recommended for children with AML in second CR only. Here, we retrospectively analyze interphase data of children who underwent HSCT ...

R Beier, M H Albert, P Bader, A Borkhardt, U Creutzig… in Bone Marrow Transplantation (2013)

Article

Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers

Adoptive immunotherapy with allogeneic purified natural killer (NK) cell products might exert graft-versus-tumor alloreactivity with little risk of GVHD. In a prospective phase II study in two centers, we admi...

M Stern, J R Passweg, S Meyer-Monard, R Esser, T Tonn… in Bone Marrow Transplantation (2013)

Article

Prospective comparison of PCR-based vs late mRNA-based preemptive antiviral therapy for HCMV infection in patients after allo-SCT

Human CMV (HCMV)-directed preemptive therapy has helped to improve the outcome following allo-SCT. In this study, we evaluated the safety and efficacy of a late mRNA-based (NucliSens CMV pp67) anti-HCMV treatm...

H Hebart, C Lengerke, P Ljungman, C V Paya, T Klingebiel… in Bone Marrow Transplantation (2011)

Article

Multivariate analyses of immune reconstitution in children after allo-SCT: risk-estimation based on age-matched leukocyte sub-populations

The speed of immune recovery after allo-SCT is of central importance to overcome infectious complications and relapse. To evaluate the immune reconstitution of pediatric patients concerning overall survival, w...

M Koenig, S Huenecke, E Salzmann-Manrique, R Esser… in Bone Marrow Transplantation (2010)

Article

Transplantation CD3/CD19-depletierter Stammzellen

Die allogene Stammzelltransplantation ist ein wichtiges und wertvolles Therapieelement in der Behandlung von vielen Patienten mit malignen und nichtmalignen Systemerkrankungen. Limitierend ist oft das Nichtvor...

Prof. Dr. P. Bader, A. Willasch, A. Jarisch, J. Soerensen… in Monatsschrift Kinderheilkunde (2010)