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  1. Article

    Correction: CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    I. Tirado-Gonzalez, E. Czlonka, A. Nevmerzhitskaya, D. Soetopo, E. Bergonzani… in Leukemia (2021)

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  2. Article

    Open Access

    CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC

    I Tirado-Gonzalez, E Czlonka, A Nevmerzhitskaya, D Soetopo, E Bergonzani… in Leukemia (2018)

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  3. No Access

    Article

    RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo

    N Jyotsana, A Sharma, A Chaturvedi, M Scherr, F Kuchenbauer, L Sajti… in Leukemia (2018)

  4. Article

    Open Access

    Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004

    We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-Berlin-Frankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosoma...

    M Rasche, C von Neuhoff, M Dworzak, J-P Bourquin, J Bradtke, G Göhring… in Leukemia (2017)

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  5. No Access

    Article

    Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

    Inhibition of anti-apoptotic BCL-2 (B-cell lymphoma 2) has recently emerged as a promising new therapeutic strategy for the treatment of a variety of human cancers, including leukemia. Here, we used T-cell acu...

    S Peirs, V Frismantas, F Matthijssens, W Van Loocke, T Pieters, N Vandamme… in Leukemia (2017)

  6. No Access

    Article

    Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

    Chromosomal rearrangements of the mixed lineage leukemia (MLL/KMT2A) gene leading to oncogenic MLL-fusion proteins occur in ~10% of acute leukemias and are associated with poor clinical outcomes, emphasizing the ...

    C Dafflon, V J Craig, H Méreau, J Gräsel, B Schacher Engstler, G Hoffman… in Leukemia (2017)

  7. No Access

    Article

    Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival

    U Creutzig, M N Dworzak, M Zimmermann, J-P Bourquin, B Gruhn, G Fleischhack… in Leukemia (2015)

  8. No Access

    Article

    Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment

    The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is poor. Here, we assessed the prognostic importance of response during induction and consolidation treatment prior to hema...

    C Eckert, N Hagedorn, L Sramkova, G Mann, R Panzer-Grümayer, C Peters… in Leukemia (2015)

  9. No Access

    Article

    An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

    Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). To date, fluorescence in situ hybridisation ...

    C J Harrison, A V Moorman, C Schwab, A J Carroll, E A Raetz, M Devidas… in Leukemia (2014)

  10. No Access

    Article

    Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy

    Histone deacetylase (HDAC) inhibitors (HDACis) are well-characterized anti-cancer agents with promising results in clinical trials. However, mechanistically little is known regarding their selectivity in killi...

    M V Stankov, M El Khatib, B Kumar Thakur, K Heitmann, D Panayotova-Dimitrova… in Leukemia (2014)

  11. No Access

    Article

    CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage

    Switches from the lymphoid to myeloid lineage during B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment are considered rare and thus far have been detected in MLL-rearranged leukemia. Here, we d...

    L Slamova, J Starkova, E Fronkova, M Zaliova, L Reznickova, F W van Delft… in Leukemia (2014)

  12. No Access

    Article

    Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report

    Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) wer...

    U Creutzig, M Zimmermann, J-P Bourquin, M N Dworzak, B Kremens, T Lehrnbecher… in Leukemia (2012)

  13. No Access

    Article

    The CALM–AF10 fusion is a rare event in acute megakaryoblastic leukemia

    O Greiner, B C Bornhauser, E Delabesse, P Ballerini, J Landman-Parker… in Leukemia (2007)

  14. No Access

    Article

    Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood

    The optimal therapy for children with relapsed or refractory acute promyelocytic leukemia (APL) is unclear. We therefore reviewed our institutional outcomes for children undergoing allogeneic hematopoietic ste...

    J P Bourquin, I Thornley, D Neuberg, L Brennan, A Kung… in Bone Marrow Transplantation (2004)

  15. No Access

    Article

    A 14-month-old boy with cardiomegaly and heart failure

    G. Junga, J. P. Bourquin, M. Albisetti, M. Fasnacht… in European Journal of Pediatrics (1998)