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  1. Article

    Open Access

    Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction

    Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy,...

    Barbara Schormair, Chen Zhao, Steven Bell, Maria Didriksen in Nature Genetics (2024)

  2. No Access

    Article

    Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease

    Urine tricarboxylic acid (TCA) cycle organic anions (OAs) are elevated in diabetes and may be biomarkers for diabetic kidney disease (DKD) progression.

    Joseph Lunyera, Clarissa J. Diamantidis, Hayden B. Bosworth, Uptal D. Patel in Metabolomics (2021)

  3. No Access

    Article

    Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease

    Low potassium intake can affect cardiovascular disease (CVD) risk and cardiometabolic risk factors.

    Ranee Chatterjee, Clemontina A. Davenport, Lydia Kwee, David D’Alessio in Metabolomics (2020)

  4. Article

    Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann in Nature Genetics (2019)

  5. Article

    Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in...

    Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann in Nature Genetics (2018)

  6. Article

    Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    In the published version of this paper, the name of author Emanuele Di Angelantonio was misspelled. This error has now been corrected in the HTML and PDF versions of the article.

    Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann in Nature Genetics (2018)

  7. No Access

    Article

    Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case–control study

    Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking.

    Nwora Lance Okeke, Damian M. Craig, Michael J. Muehlbauer, Olga Ilkayeva in Metabolomics (2018)

  8. No Access

    Article

    Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants fro...

    Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann in Nature Genetics (2018)

  9. Article

    Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

    Nat. Genet.; 10.1038/ng.3843; corrected online 11 May 2017 In the version of this article initially published online, the authors were incorrectly defined as members of the AFGen consortium in the author list....

    Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, **aoyan Yin in Nature Genetics (2017)

  10. No Access

    Article

    Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

    Patrick Ellinor and colleagues report meta-analyses of common and rare variant association studies for atrial fibrillation across multiple populations. They identify 12 new loci, some of which implicate genes ...

    Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, **aoyan Yin in Nature Genetics (2017)

  11. No Access

    Article

    A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience

    The CATHeterization GENetics (CATHGEN) biorepository was assembled in four phases. First, project start-up began in 2000. Second, between 2001 and 2010, we collected clinical data and biological samples from 9...

    William E. Kraus, Christopher B. Granger in Journal of Cardiovascular Translational Re… (2015)

  12. No Access

    Article

    Large-scale association analysis identifies new risk loci for coronary artery disease

    Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and 130,681 controls. They identify 15 susceptibility l...

    Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall in Nature Genetics (2013)

  13. No Access

    Article

    Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

    Solveig Gretarsdottir, Kari Stefansson and colleagues report a genome-wide association study for abdominal aortic aneurysm. They identified a variant located within the DAB2IP gene on 9q33 associated with risk of...

    Solveig Gretarsdottir, Annette F Baas, Gudmar Thorleifsson, Hilma Holm in Nature Genetics (2010)

  14. No Access

    Article

    Genetics of cardiac repolarization

    Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, is associated with arrhythmogenic disorders and is a risk factor for sudden cardiac death. Two genome-wide association...

    Svati H Shah, Geoffrey S Pitt in Nature Genetics (2009)

  15. No Access

    Article

    Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

    Daniel Gudbjartsson and colleagues report results of a genome-wide association study for loci influencing eosinophil counts. Follow-up studies showed that a subset of the variants identified in this screen wer...

    Daniel F Gudbjartsson, Unnur S Bjornsdottir, Eva Halapi in Nature Genetics (2009)

  16. No Access

    Article

    The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

    Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)1,2,3,4 and type 2 diabetes (T2D)5,6,7, respectively. We p...

    Anna Helgadottir, Gudmar Thorleifsson, Kristinn P Magnusson in Nature Genetics (2008)