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  1. Article

    Open Access

    Transitioning to active-controlled trials to evaluate cardiovascular safety and efficacy of medications for type 2 diabetes

    Cardiovascular (CV) outcome trials (CVOTs) of type 2 diabetes mellitus (T2DM) therapies have mostly used randomized comparison with placebo to demonstrate non-inferiority to establish that the investigational ...

    Darren K. McGuire, David D’Alessio, Stephen J. Nicholls… in Cardiovascular Diabetology (2022)

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  2. No Access

    Article

    Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease

    Low potassium intake can affect cardiovascular disease (CVD) risk and cardiometabolic risk factors.

    Ranee Chatterjee, Clemontina A. Davenport, Lydia Kwee, David D’Alessio… in Metabolomics (2020)

  3. No Access

    Article

    One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

    Stimulation of the glucagon-like peptide-1 (GLP1) receptor is a useful treatment strategy for type 2 diabetes due to pleiotropic effects, such as the regulation of islet hormones and the induction of satiety. ...

    Kelli M. Luginbuhl, Jeffrey L. Schaal, Bret Umstead… in Nature Biomedical Engineering (2017)

  4. Article

    The role of the transcription factor ETV5 in insulin exocytosis

    Genome-wide association studies have revealed an association of the transcription factor ETS variant gene 5 (ETV5) with human obesity. However, its role in glucose homeostasis and energy balance is unknown.

    Ruth Gutierrez-Aguilar, Dong-Hoon Kim, Marina Casimir, **ao-Qing Dai… in Diabetologia (2014)

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  5. No Access

    Article

    Cooperation between brain and islet in glucose homeostasis and diabetes

    An alternative view of diabetes is presented in which blood glucose homeostasis is achieved via collective actions of two regulatory systems: a brain-centred glucoregulatory system (BCGS), which works together...

    Michael W. Schwartz, Randy J. Seeley, Matthias H. Tschöp, Stephen C. Woods… in Nature (2013)

  6. No Access

    Article

    Chylomicron Formation and Secretion is Required for Lipid-Stimulated Release of Incretins GLP-1 and GIP

    Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. Circulating ...

    Wendell J. Lu, Qing Yang, Li Yang, Dana Lee, David D’Alessio, Patrick Tso in Lipids (2012)

  7. No Access

    Article

    Ghrelin, obesity and diabetes

    Although it affects food intake and energy partitioning, the precise role of the various forms of ghrelin and its receptor(s) in energy balance remains unclear. As described here, its specific effects on gluco...

    Petra Wiedmer, Rubén Nogueiras… in Nature Clinical Practice Endocrinology & M… (2007)

  8. No Access

    Article

    C75 inhibits food intake by increasing CNS glucose metabolism

    Matthew D. Wortman, Deborah J. Clegg, David D'Alessio, Stephen C. Woods… in Nature Medicine (2003)