29 Result(s)
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Michael J. Muehlbauer
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Article
Open AccessSexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is...
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Metabolomic and genetic architecture of gestational diabetes subtypes
Physiological gestational diabetes mellitus (GDM) subtypes that may confer different risks for adverse pregnancy outcomes have been defined. The aim of this study was to characterise the metabolome and genetic...
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Open AccessPrevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, im...
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Open AccessCirculating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry
The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether circulating...
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Open AccessCorrection: Path-level interpretation of Gaussian graphical models using the pair-path subscore
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Open AccessAssociation of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study
There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% conf...
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Open AccessPath-level interpretation of Gaussian graphical models using the pair-path subscore
Construction of networks from cross-sectional biological data is increasingly common. Many recent methods have been based on Gaussian graphical modeling, and prioritize estimation of conditional pairwise depen...
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Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease
Urine tricarboxylic acid (TCA) cycle organic anions (OAs) are elevated in diabetes and may be biomarkers for diabetic kidney disease (DKD) progression.
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Open AccessA metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels
A new generation of plant-based meat alternatives—formulated to mimic the taste and nutritional composition of red meat—have attracted considerable consumer interest, research attention, and media coverage. Th...
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Open AccessBranched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-13C-labeled α-ketoisoval...
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Open AccessMetabolites and diabetes remission after weight loss
There is marked heterogeneity in the response to weight loss interventions with regards to weight loss amount and metabolic improvement. We sought to identify biomarkers predictive of type 2 diabetes remission...
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Metabolomic and genetic associations with insulin resistance in pregnancy
Our study aimed to integrate maternal metabolic and genetic data related to insulin sensitivity during pregnancy to provide novel insights into mechanisms underlying pregnancy-induced insulin resistance.
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Open AccessNon-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction
Our objective was to identify metabolites associated with fetal growth restriction (FGR) by examining early and late pregnancy differences in non-targeted urinary metabolites among FGR cases and non-FGR contro...
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Open AccessDisrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure
Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Her...
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Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries
We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn dyads.
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Open AccessTen weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study
Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and inc...
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Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case–control study
Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking.
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Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats
The effects of exercise on the heart and its resistance to disease are well-documented. Recent studies have identified that exercise-induced resistance to arrhythmia is due to the preservation of mitochondrial...
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Article
Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes
Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediat...
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Open AccessMixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
Metabolomics offers a unique integrative perspective for health research, reflecting genetic and environmental contributions to disease-related phenotypes. Identifying robust associations in population-based o...
