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Article
Open AccessAllometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis
Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (...
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Article
Open AccessProbing the diabetes and colorectal cancer relationship using gene – environment interaction analyses
Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic vari...
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Article
Open AccessGenetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
Epidemiological studies have generated conflicting findings on the relationship between glucose-lowering medication use and cancer risk. Naturally occurring variation in genes encoding glucose-lowering drug ta...
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Article
Open AccessRisk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies
Persistent infection by oncogenic human papillomavirus (HPV) is necessary although not sufficient for development of cervical cancer. Behavioural, environmental, or comorbid exposures may promote or protect ag...
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Article
Open AccessCirculating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to exa...
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Article
Open AccessAwareness, knowledge and trust in the Greek authorities towards COVID-19 pandemic: results from the Epirus Health Study cohort
To assess the level of knowledge and trust in the policy decisions taken regarding the coronavirus disease (COVID-19) pandemic among Epirus Health Study (EHS) participants.
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Article
Open AccessEndogenous sex steroid hormones and colorectal cancer risk: a systematic review and meta-analysis
Preclinical data suggest that endogenous sex steroid hormones may be implicated in colorectal cancer (CRC) development, however, findings from epidemiological studies are conflicting. The aim of this systemati...
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Article
Open AccessMeinteR: A framework to prioritize DNA methylation aberrations based on conformational and cis-regulatory element enrichment
DNA methylation studies have been reformed with the advent of single-base resolution arrays and bisulfite sequencing methods, enabling deeper investigation of methylation-mediated mechanisms. In addition to th...
