14 Result(s)
within
Simon Clare
Science, Humanities and Social Sciences, multidisciplinary
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Article
IFITM3 restricts the morbidity and mortality associated with influenza
Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic ca...
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Open AccessThe Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions
Salmonella Typhi, the causative agent of typhoid fever, is a monophyletic, human-restricted bacterium that exhibits limited phenotypic variation. S. Typhi from Indonesia are a notable exception, with circulating ...
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Article
Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway
Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development requires Bcl11b and IL-25R expression; activated ILCs c...
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Article
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization
Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.
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Open AccessPreclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease
TNFα is an important cytokine in inflammatory bowel disease. V565 is a novel anti-TNFα domain antibody developed for oral administration in IBD patients, derived from a llama domain antibody and engineered to ...
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Open AccessAlpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum of genetic and environmental factors. In mice, overlap** regions of chromosome 3 have been assoc...
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Open AccessAn African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation
Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the anti...
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Open AccessEstablishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening
Visceral leishmaniasis is an infectious parasitic disease caused by the protozoan parasites Leishmania donovani and Leishmania infantum. The drugs currently used to treat visceral leishmaniasis suffer from toxici...
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Open AccessGenomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae
In order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease ove...
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Gut-educated IgA plasma cells defend the meningeal venous sinuses
The central nervous system has historically been viewed as an immune-privileged site, but recent data have shown that the meninges—the membranes that surround the brain and spinal cord—contain a diverse popula...
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Open AccessAuthor Correction: Establishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
An invariant Trypanosoma vivax vaccine antigen induces protective immunity
Trypanosomes are protozoan parasites that cause infectious diseases, including African trypanosomiasis (slee** sickness) in humans and nagana in economically important livestock1,2. An effective vaccine against...
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Open AccessPreclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease
Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn’s disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL...
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Open AccessTissue-resident B cells orchestrate macrophage polarisation and function
B cells play a central role in humoral immunity but also have antibody-independent functions. Studies to date have focused on B cells in blood and secondary lymphoid organs but whether B cells reside in non-ly...
