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Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
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Latent human herpesvirus 6 is reactivated in CAR T cells
Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a ...
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Open AccessGene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma
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Open AccessA Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report...
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Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1
The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establi...
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Correction: Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature 517, 386–390 (2015); doi:10.1038/nature13848 In this Letter, we published the crystal structure of a heterodimer of the human (h)CEACAM1 IgV domain and hTIM-3 IgV domain (Protein Data Bank (PDB) accessi...
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Open AccessIdentification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation
Fingolimod (FTY720), the first oral treatment for multiple sclerosis (MS), blocks immune cell trafficking and prevents disease relapses by downregulation of sphingosine-1-phosphate receptor. We determined the ...
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Correction: Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction
Nature Communications 6, Article number: 6072 (2015); Published 23 January 2015; Updated 8 July 2015 In the Discussion section of this Article, we inadvertently stated that ‘endogenous IL-27 signalling results...
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An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
The inhibitory receptor T-cell immunoglobulin and mucin domain-3 (Tim-3) has emerged as a critical regulator of the T-cell dysfunction that develops in chronic viral infections and cancers. However, little is ...
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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
CEACAM1 functions as a novel heterophilic ligand for TIM-3 and is necessary for TIM-3-mediated tolerance, which has marked consequences for inflammation, infection and cancer.
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Open AccessLv4, an activity that restricts nuclear entry of SIVMAC/SIVSM in human blood cells
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IFITM3 restricts the morbidity and mortality associated with influenza
Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic ca...
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Open AccessVpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
Vpx is a virion-associated protein encoded by SIVSM, a lentivirus endemic to the West African sooty mangabey (Cercocebus atys). HIV-2 and SIVMAC, zoonoses resulting from SIVSM transmission to humans or Asian rhes...
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TRIM5 is an innate immune sensor for the retrovirus capsid lattice
TRIM5 is an E3 ubiquitin ligase with known antiretroviral restriction factor activity, although the mechanisms involved are poorly understood. Luban and colleagues now demonstrate that TRIM5 activates innate i...
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Open AccessTRIM5alpha contributes to the anti-viral state
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Growth Inhibitory Activity of Extracts and Purified Components of Black Cohosh on Human Breast Cancer Cells
The purpose of this study was to determine whether black cohosh contains constituents that inhibit the growth of human breast cancer cells, and therefore might eventually be useful in the prevention or treatme...
