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  1. No Access

    Article

    Venous-plexus-associated lymphoid hubs support meningeal humoral immunity

    There is increasing interest in how immune cells in the meninges—the membranes that surround the brain and spinal cord—contribute to homeostasis and disease in the central nervous system1,2. The outer layer of th...

    Zachary Fitzpatrick, Nagela Ghabdan Zanluqui, Jared S. Rosenblum… in Nature (2024)

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    Article

    Gut-educated IgA plasma cells defend the meningeal venous sinuses

    The central nervous system has historically been viewed as an immune-privileged site, but recent data have shown that the meninges—the membranes that surround the brain and spinal cord—contain a diverse popula...

    Zachary Fitzpatrick, Gordon Frazer, Ashley Ferro, Simon Clare, Nicolas Bouladoux… in Nature (2020)

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    Article

    Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery

    The malignant primary brain tumor, glioblastoma (GBM) is generally incurable. New approaches are desperately needed. Adeno-associated virus (AAV) vector-mediated delivery of anti-tumor transgenes is a promisin...

    Adrienn Volak, Stanley G. LeRoy, Jeya Shree Natasan… in Journal of Neuro-Oncology (2018)