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Article
Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system
CD4+ T helper 17 (TH17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing processes remain unclear. Here, we found that the transcription factor EGR2 controlled the...
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Article
Open AccessA mouse model of occult intestinal colonization demonstrating antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae
The human intestinal microbiome is a complex community that contributes to host health and disease. In addition to normal microbiota, pathogens like carbapenem-resistant Enterobacteriaceae may be asymptomatically...
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Article
Gut-educated IgA plasma cells defend the meningeal venous sinuses
The central nervous system has historically been viewed as an immune-privileged site, but recent data have shown that the meninges—the membranes that surround the brain and spinal cord—contain a diverse popula...
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Article
Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism
Distinct populations of lymphocytes act sequentially during development to direct maturation of the mammalian gut microbiota.
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Protocol
Hapten-Specific T Cell-Mediated Skin Inflammation: Flow Cytometry Analysis of Mouse Skin Inflammatory Infiltrate
Hapten-specific T cell-mediated skin inflammation also known as contact hypersensitivity (CHS) is characterized by a strong influx of CD8+ cytotoxic T cells within the skin upon reexposure of sensitized individua...
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Article
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
Defined skin commensal bacteria elicit a dermal dendritic-cell-dependent, long-lasting, commensal-specific CD8+ T-cell response that promotes protection against pathogens while preserving tissue homeostasis.
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Article
A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells
The transcription factor ThPOK promotes CD4+ T cell differentiation in the thymus. Bosselut and colleagues show that ThPOK maintains CD4+ T lineage integrity and is required for proper TH1 and TH2 differentiation...
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Article
Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection
Monocytes play an important part in the clearance of pathogens during infection. Yasmine Belkaid and her colleagues now report that inflammatory monocytes can also have a regulatory role. Specifically, these c...
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Article
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
T-helper 17 (TH17) cells are a subset of T-helper cells that produce interleukin (IL)-17 and are critical for host immunity. IL-6 and transforming growth factor-β (TGF-β) had been thought of as the principal indu...
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Article
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
The protease furin is induced on T cell activation and is a target of Stat-transcription factors in T cells. Studying furin has been hampered by the fact that germline deletion of this gene is embryonically le...
