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  1. Article

    Open Access

    LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM

    De novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, the mechanisms underlying gastric cancer (GC) resistance to chemother...

    Feifei Zhang, Hui Wang, Jiang Yu, Xueqing Yao, Shibin Yang, Weidong Li… in Molecular Cancer (2021)

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  2. No Access

    Article

    LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion

    LIM and SH3 protein 1 (LASP1) is a metastasis-related protein reported to enhance tumour progression in colorectal cancer (CRC). However, the underlying mechanism is still elusive. As the major biological and ...

    **** Yan, Jian Liu, Rui Zhou, Chuang Lin, Kunhe Wu, Shibin Yang, Shuai Yang… in Oncogene (2020)

  3. Article

    Open Access

    High copy number and highly stable Escherichia coli–Bacillus subtilis shuttle plasmids based on pWB980

    pWB980 derived from pUB110 is a promising expression vector in Bacillus for its high copy number and high stability. However, the low transformation rate of recombinant plasmids to the wild cells limited the appl...

    **ngYa Zhao, JianYong Xu, Ming Tan, Jie Zhen, WenJu Shu… in Microbial Cell Factories (2020)

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  4. No Access

    Article

    High-level extracellular production of an alkaline pectate lyase in E. coli BL21 (DE3) and its application in bioscouring of cotton fabric

    A high heterologous expression of an alkaline pectate lyase (APL) pelNK93I in E. coli was obtained through optimizing the lactose feeding and fed-batch fermentation. The highest soluble APL activity produced by E...

    Jie Zhen, Ming Tan, ** Fu, Wenju Shu, **ngya Zhao, Shibin Yang… in 3 Biotech (2020)

  5. No Access

    Article

    Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

    Metastasis is a complex process that requires the interaction between tumor cells and their microenvironment. As an important regulator of intestinal microenvironment, gut microbiota plays a significant role i...

    Rui Li, Rui Zhou, Hui Wang, Weidong Li, Mingxin Pan… in Cell Death & Differentiation (2019)

  6. No Access

    Article

    Ethanol effects on the overexpression of heterologous catalase in Escherichia coli BL21 (DE3)

    A novel method involving ethanol-induced increase in the heterologous recombinant protein expression in E. coli cells was commonly used in recent studies. However, the detailed mechanism of this method is still t...

    Hongchen Zheng, Zhenxiao Yu, Wenju Shu… in Applied Microbiology and Biotechnology (2019)

  7. No Access

    Article

    Construction of a plasmid interspecific transfer system in Bacillus species with the counter-selectable marker mazF

    Bacillus sp. strains as attractive hosts for the production of heterologous secretory proteins usually play important roles in bio-industry. However, low transformation efficiency of exogenous plasmids limited th...

    **ngYa Zhao, JianYong Xu, Ming Tan… in Journal of Industrial Microbiology & Biote… (2018)

  8. No Access

    Article

    Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT

    Membrane type 1-matrix metalloproteinase (MT1-MMP) has been identified to play a significant role in several types of cancers, but little is known about the significance of MT1-MMP in gastric cancer patients. ...

    Wenfeng Li, Shouzhi Li, Liang Deng, Shibin Yang, Mingzhe Li, Shuo Long… in Tumor Biology (2015)

  9. No Access

    Article

    Susceptibility and REF1 Gene Polymorphism Towards Colorectal Cancer

    Published data on the relation between REF1 polymorphism and colorectal cancer risk showed inconclusive results. The aim of this study was to derive a comprehensive estimation of the association. Data on assoc...

    Shibin Yang, Yuanhui Lai, Longbin **ao, Fanghai Han… in Cell Biochemistry and Biophysics (2015)