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Susceptibility and REF1 Gene Polymorphism Towards Colorectal Cancer

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Abstract

Published data on the relation between REF1 polymorphism and colorectal cancer risk showed inconclusive results. The aim of this study was to derive a comprehensive estimation of the association. Data on association between REF1 polymorphism and colorectal cancer risk were summarized. The association was estimated by calculating an odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) with the fixed effects model when P > 0.1 (from heterogeneity test) or with the random effects model when P < 0.1. No significant association was revealed in any genetic model assumed for the overall analysis (OR = 1.03, 95 % CI = 0.81–1.32 for Glu/Glu vs. Asp/Asp; OR = 1.05, 95 % CI = 0.96–1.15 for Glu/Glu + Asp/Glu vs. Asp/Asp; OR = 0.97, 95 % CI = 0.76–1.23 for Glu/Glu vs. Asp/Glu + Asp/Asp; OR = 1.03, 95 % CI = 0.92–1.16 for Glu vs. Asp; OR = 1.09, 95 % CI = 0.93–1.27 for Asp/Glu vs. Asp/Asp). In Caucasian population, nor did we find a significant association. This research indicates that REF1 polymorphism is unlikely to be associated with colorectal cancer risk.

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The authors have not declared any conflicts of interest.

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Authors and Affiliations

  1. Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510700, Guangdong, China

    Shibin Yang, Longbin **ao, Fanghai Han, Wenhui Wu, Shuo Long, Wenfeng Li & Yulong He

  2. Department of General Surgery I, Huangpu Division of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510700, China

    Yuanhui Lai

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  1. Shibin Yang
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  2. Yuanhui Lai
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  3. Longbin **ao
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  4. Fanghai Han
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  6. Shuo Long
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  7. Wenfeng Li
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  8. Yulong He
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Correspondence to Longbin **ao.

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Yang, S., Lai, Y., **ao, L. et al. Susceptibility and REF1 Gene Polymorphism Towards Colorectal Cancer. Cell Biochem Biophys 71, 977–982 (2015). https://doi.org/10.1007/s12013-014-0296-7

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  • DOI: https://doi.org/10.1007/s12013-014-0296-7

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