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Article
Predominance of MGMT promoter methylation among Pakistani glioblastoma patients
Glioblastoma multiforme (GBM), the most prevalent subgroup of neuroepithelial tumors, is characterized by dismal overall survival (OS). Several studies have linked O6-methylguanine-DNA-methyltransferase (MGMT) pr...
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Article
Rooftop rainwater harvesting potential for kitchen gardening in the Rawal watershed, Pakistan
Conserving rainwater at the household level is generally overlooked in many develo** countries. Therefore, rooftop rainwater potential for kitchen gardening or aquifer recharge was explored using 30 years of...
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Article
Open AccessSouth Asian medical cohorts reveal strong founder effects and high rates of homozygosity
The benefits of large-scale genetic studies for healthcare of the populations studied are well documented, but these genetic studies have traditionally ignored people from some parts of the world, such as Sout...
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Article
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other stu...
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Article
First report of barley yellow dwarf virus PAV in uncultivated grasses of Pakistan
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Article
Synthesis of new chiral 1,3,4-thiadiazole-based di- and tri-arylsulfonamide residues and evaluation of in vitro anti-HIV activity and cytotoxicity
A series of new chiral 1,3,4-thiadiazole-based bis-sulfonamides 4a–4w and tri-sulfonamide analogue 5 was synthesized and evaluated as anti-HIV agents. The reaction of chiral amino acids 1 with sulfonyl chlorides
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Article
Open AccessSynthesis and characterization of novel iminobenzoates with terminal pyrazine moieties
Apart from its numerous biological activities like antidiabetic, anti-inflammatory, antimicrobial, pyrazine moiety plays an important role in luminescent materials. Its role in luminescent materials is due to ...
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Article
Synthesis and crystal structure of bis-chalcone-derived fused-ring pyrazoline having an unusual substitution pattern
Pyrazolines are an important class of heterocyclic compounds with diverse applications. A novel bis-chalcone-derived fused ring pyrazoline has been obtained by the reaction of bis-chalcone with hydrazine hydra...
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Article
Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new pyrazolylthiazole derivatives
The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors offers the possibility of generating novel structures of increased potency. Based on the bioisosteric principle, new series of N′-benzy...
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Article
Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new oxadiazole and thiazole analogs
A series of 2-adamantyl-5-arylthiazolyl-1,3,4-oxadiazoles 7a–x together with thiazoles 13 and 14 were synthesized. Compounds 7a–l, 13, and 14 were tested in vitro with the aim of identifying novel lead compounds ...
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Article
Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives
A series of new 3-arylsulfonylimidazolidine-2,4-diones (2a–2p) were synthesized by reacting imidazolidine-2,4-diones (1a–1e) with arylsulfonyl chlorides in the presence of triethyl amine. The imidazolidine-2,4-d...
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Article
Neuronal expression of the intermediate conductance calcium-activated potassium channel KCa3.1 in the mammalian central nervous system
The expression pattern and functional roles for calcium-activated potassium channels of the KCa2.x family and KCa1.1 have been extensively examined in central neurons. Recent work indicates that intermediate c...
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Article
Luteovirus: insights into pathogenicity
Luteoviruses are economically important plant viruses, infecting almost all cereals throughout the world. Idiosyncrasies related to this virus group may be a strategic consequence of viral genome compression. ...
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Article
Synthesis, characterization, and hypoglycemic activity of 3-(arylsulfonyl)spiroimidazolidine-2,4-diones
Spiroimidazolidine-2,4-diones were prepared from methylcyclohexanones by the Bucherer–Bergs reaction. Synthesis of the target 3-(arylsulfonyl)spiroimidazolidine-2,4-diones was achieved by reaction of arylsulfo...
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Article
Design, synthesis, and urease inhibition studies of a series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones
A series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones was synthesized by reaction of aryl hydrazides with CS2 and hydrazine hydrate. The synthesized compounds were characterized by spectroanalytical techniques, ...
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Article
Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes
A-type potassium currents determine a neuron's firing characteristics. Anderson et al. find that Cav3 calcium channels complex with Kv4 potassium channels, such that Ca2+ influx through T-type channels via the ca...
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Article
ORL1 receptor–mediated internalization of N-type calcium channels
The inhibition of N-type calcium channels by opioid receptor like receptor 1 (ORL1) is a key mechanism for controlling the transmission of nociceptive signals. We recently reported that signaling complexes con...
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Article
An Unexpected Synthesis of Novel Oxygen-Bridged 1,5-Benzothiazepine Derivatives and their Reductive Five-Membered-Ring Opening
A convenient procedure is reported for the preparation of benzofuro-annelated 2-phenyl-1,5-benzothiazepine derivatives by oxidative cyclocondensation of phenolic β-diketones with o-aminothiophenol in DMSO. The r...
