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Article
Predominance of MGMT promoter methylation among Pakistani glioblastoma patients
Glioblastoma multiforme (GBM), the most prevalent subgroup of neuroepithelial tumors, is characterized by dismal overall survival (OS). Several studies have linked O6-methylguanine-DNA-methyltransferase (MGMT) pr...
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Article
Epithelioid and spindle cell rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusion: report of two cases
The WHO Classification of Tumors of Soft Tissue and Bone divides rhabdomyosarcoma (RMS) into alveolar, embryonal, pleomorphic, and spindle cell/sclerosing types. Advances in molecular diagnostics have allowed ...
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Chapter
Desmoid Fibromatosis and Dermatofibrosarcoma Protuberans
Desmoid tumors (DTs) and dermatofibrosarcoma protuberans (DFSP) are rare mesenchymal neoplasms. Most DTs arise sporadically, but 5–10% are associated with familial adenomatous polyposis (FAP). Management has s...
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Chapter
Retroperitoneal and Extremity Soft Tissue Sarcomas
Soft tissue sarcomas (STS) are a heterogeneous group of rare malignant neoplasms of mesenchymal origin. Appropriate workup and management vary according to anatomic site of origin and histologic subtype. This ...