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Open AccessReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement
ReIMAGINE aims to improve the current prostate specific antigen (PSA)/biopsy risk stratification for prostate cancer (PCa) and develop a new image-based method (with biomarkers) for diagnosing high/low risk PC...
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Open AccessIntroduction to the National Cancer Imaging Translational Accelerator (NCITA): a UK-wide infrastructure for multicentre clinical translation of cancer imaging biomarkers
The National Cancer Imaging Translational Accelerator (NCITA) is creating a UK national coordinated infrastructure for accelerated translation of imaging biomarkers for clinical use. Through the development of...
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Measurement of liver and spleen interstitial volume in patients with systemic amyloid light-chain amyloidosis using equilibrium contrast CT
To investigate equilibrium contrast-enhanced CT (EQ-CT) measurement of extracellular volume fraction (ECV) in patients with systemic amyloid light-chain (AL) amyloidosis, testing the hypothesis that ECV become...
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Magnetic resonance imaging targeted transperineal prostate biopsy: a local anaesthetic approach
Despite high rates of disease misclassification and sepsis, the use of transrectal biopsy remains commonplace. Transperineal map** biopsies mitigate these problems but carry increased cost and patient burden...
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Open AccessEvolution of multi-parametric MRI quantitative parameters following transrectal ultrasound-guided biopsy of the prostate
To determine the evolution of prostatic multi-parametric magnetic resonance imaging (mp-MRI) signal following transrectal ultrasound (TRUS)-guided biopsy.
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Multiparametric MRI for detection of radiorecurrent prostate cancer: added value of apparent diffusion coefficient maps and dynamic contrast-enhanced images
Multiparametric magnetic resonance imaging (mp-MRI) is increasingly advocated for prostate cancer detection. There are limited reports of its use in the setting of radiorecurrent disease. Our aim was to assess...
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Role of focal salvage ablative therapy in localised radiorecurrent prostate cancer
Up to one-third of men can fail radical external beam radiotherapy for primary prostate cancer. Most of these men have expectant management with delayed hormones. However, around half of these men have locali...
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Measurement of colonic polyps by radiologists and endoscopists: Who is most accurate?
The purpose was to determine the accuracy of polyp measurement by endoscopy and CT. A colonic phantom was constructed containing 12 simulated polyps of known diameter. Polyp diameter was estimated during endos...
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Non-invasive quantification of pancreatic exocrine function using secretin-stimulated MRCP
Our objective was to quantify water volume using magnetic resonance cholangiopancreatography (MRCP) sequences and apply this to secretin-stimulated studies with the aim of quantifying pancreatic exocrine func...
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Magnesium Sulfate after Transient Hypoxia-Ischemia Fails to Prevent Delayed Cerebral Energy Failure in the Newborn Piglet
Severely birth-asphyxiated human infants develop delayed(“secondary”) cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis that i.v. magn...
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NMR Studies of Hypoxic-Ischaemic Injury in Neonatal Brain Using Imaging and Spectroscopy
Brain injury arising in the perinatal period leads to death or permanent and severe impairment in more than 1000 infants per year in the UK (Alberman and Botting, 1991). The aim of this work is to use nuclear ...
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Chapter
Correlation between Absolute Deoxyhaemoglobin [dHb] Measured by Near Infrared Spectroscopy (NIRS) and Absolute R2′ as Determined by Magnetic Resonance Imaging (MRI)
Magnetic Resonance Imaging (MRI) is a technique which provides high spatial resolution combined with a wide range of image contrast mechanisms. Standard MR image contrast relies upon tissue differences in MR v...
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Reduced Apparent Diffusion Coefficient (ADC) and Impaired Cerebral Energy Generation in the Newborn Piglet Brain Following Acute Hypoxia-Ischaemia. 7
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Magnesium SULPHATE (MgSO4) DOES NOT PREVENT DELAYED CEREBRAL ENERGY FAILURE FOLLOWING TRANSIENT HYPOXIA-ISCHAEMIA IN THE PIGLET. 188